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- Title
Multi-institutional analysis of T3 subtypes and adjuvant radiotherapy effects in resected T3N0 non-small cell lung cancer patients.
- Authors
Yunseon Choi; Ik Jae Lee; Chang Young Lee; Jae Ho Cho; Won Hoon Choi; Hong In Yoon; Yun-Han Lee; Chang Geol Lee; Ki Chang Keum; Kyung Young Chung; Seok Jin Haam; Hyo Chae Paik; Kang Kyoo Lee; Sun Rock Moon; Jong-Young Lee; Kyung-Ran Park; Young Suk Kim
- Abstract
Purpose: We evaluated the prognostic significance of T3 subtypes and the role of adjuvant radiotherapy in patients with resected the American Joint Committee on Cancer stage IIB T3N0M0 non-small cell lung cancer (NSCLC). Materials and Methods: T3N0 NSCLC patients who underwent resection from January 1990 to October 2009 (n = 102) were enrolled and categorized into 6 subgroups according to the extent of invasion: parietal pleura chest wall invasion, mediastinal pleural invasion, diaphragm invasion, separated tumor nodules in the same lobe, endobronchial tumor <2 cm distal to the carina, and tumor-associated collapse. Results: The median overall survival (OS) and disease-free survival (DFS) were 55.3 months and 51.2 months, respectively. In postoperative T3N0M0 patients, the tumor size was a significant prognostic factor for survival (OS, p = 0.035 and DFS, p = 0.035, respectively). Patients with endobronchial tumors within 2 cm of the carina also showed better OS and DFS than those in the other T3 subtypes (p = 0.018 and p = 0.016, respectively). However, adjuvant radiotherapy did not cause any improvement in survival (OS, p = 0.518 and DFS, p = 0.463, respectively). Only patients with mediastinal pleural invasion (n = 25) demonstrated improved OS and DFS after adjuvant radiotherapy (n = 18) (p = 0.012 and p = 0.040, respectively). Conclusion: The T3N0 NSCLC subtype that showed the most favorable prognosis is the one with endobronchial tumors within 2 cm of the carina. Adjuvant radiotherapy is not effective in improving survival outcome in resected T3N0 NSCLC.
- Subjects
CANCER treatment; NON-small-cell lung carcinoma; LUNG cancer prognosis; CANCER radiotherapy research; ONCOLOGIC surgery; TUMOR classification
- Publication
Radiation Oncology Journal, 2015, Vol 33, Issue 2, p75
- ISSN
2234-1900
- Publication type
Article
- DOI
10.3857/roj.2015.33.2.75