We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
CRBN is downregulated in lung cancer and negatively regulates TLR2, 4 and 7 stimulation in lung cancer cells.
- Authors
Kim, Mi‐Jeong; Lee, Ji Su; Kim, Ji Young; Choi, Bongkum; Son, Juhee; Min, Yoon; Jeong, Soo‐Kyung; Kim, Duk‐Hwan; Lee, Joo Sang; Chun, Eunyoung; Lee, Ki‐Young
- Abstract
Among upregulated genes, 12 genes (Figure 2A and Table S18) in A549 cells and 21 genes (Figure 2B and Table S19) in H1299 cells have been involved in lung cancer progression. Eventually, autophagy and these cytokines facilitate TLR2-, TLR4- and TLR7-induced lung cancer progression gl In summary, CRBN is downregulated in lung cancer cells and associated with lung cancer progression (Figure 4E, upper right). Lastly, we found that I CRBN i KO A549 cells treated with TLR agonists significantly increased single-cell mobility and the number of colonies compared to those of Ctrl A549 cells (Figure 4A,B, single-cell mobility; Figure 4C,D, number of colonies).
- Subjects
LUNG cancer; CANCER cells; AUTOPHAGY; NON-small-cell lung carcinoma
- Publication
Clinical & Translational Medicine, 2022, Vol 12, Issue 9, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.1050