We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Alternative lengthening of telomeres is mechanistically linked to potential therapeutic vulnerability in the stem‐like subtype of gastric cancer.
- Authors
Sung, Ji‐Yong; Cheong, Jae‐Ho
- Abstract
(F) Bar graph showing differentially expressed genes in TMM: three TEL genes and six ALT genes for ALT-like, 20 TEL genes and 27 ALT genes for non-ALT were significantly differentially expressed. Further, we predicted that the telomere length would be very short because of the high I PML i expression level in non-ALT tumors compared with that in ALT-like tumors of the Cancer Genome Atlas Stomach Adenocarcinoma (TCGA STAD) cohort.4 Moreover, upregulated expression of I PML i and I KI67 i has been observed in colorectal tumors with short telomeres.9 Thirty-nine ALT and 57 mitochondrial biogenesis genes showed positive and negative correlation patterns, respectively (Figure 3A). Alternative lengthening of telomeres (ALT) is a telomere maintenance mechanism (TMM) frequently observed in recalcitrant cancer. Abbreviations: Alternative lengthening of telomeres (ALT); epithelial-mesenchymal transition (EMT); gastric cancer (GC); and telomere maintenance mechanism (TMM) gl Among 10 ALT phenotypes, the Y497 cohort exhibited enhanced PPAR pathway activation and upregulated glucocorticoid receptor expression (Figure 2B).
- Subjects
STOMACH cancer; ALANINE aminotransferase; TELOMERES; CELLULAR signal transduction; OVERALL survival; COLORECTAL cancer
- Publication
Clinical & Translational Medicine, 2021, Vol 11, Issue 9, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.561