We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Matrix‐assisted laser desorption ionization ‐ mass spectrometry imaging of erlotinib reveals a limited tumor tissue distribution in a non‐small‐cell lung cancer mouse xenograft model.
- Authors
Kim, Tae Young; Lee, Boram; Kim, Yonghyo; Sugihara, Yutaka; Rezeli, Melinda; Szasz, A. Marcell; Dome, Balazs; Marko‐Varga, Gyorgy; Kwon, Ho Jeong
- Abstract
Matrix-assisted laser desorption ionization - mass spectrometry imaging of erlotinib reveals a limited tumor tissue distribution in a non-small-cell lung cancer mouse xenograft model GLO:F2H7/01jul21:ctm2481-fig-0002.jpg PHOTO (COLOR): 2 Erlotinib-resistant mouse xenograft model with H1299 cells and erlotinib distribution in tumor, liver, and kidney tissue. Although erlotinib still has a binding affinity to the target protein, EGFR, even in the H1299 tumor cells, the reduced distribution within in tumor tissues suggests a new mechanism of erlotinib resistance I in vivo i . H1299 tumor tissue, liver, and kidney were isolated from the xenograft mice previously treated with either vehicle ( I N i = 4) or erlotinib ( I N i = 5) (10 mg/kg) for analyzing erlotinib distribution.
- Subjects
MATRIX-assisted laser desorption-ionization; LABORATORY mice; NON-small-cell lung carcinoma; ERLOTINIB; MASS spectrometry; DRUG resistance; ANIMAL disease models
- Publication
Clinical & Translational Medicine, 2021, Vol 11, Issue 7, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.481