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- Title
The influence of Tigason' (Ro 10-9359) on the serum lipoproteins in man.
- Authors
Michaëlsson, G.; Bergqvist, A.; Vahlquist, A.; Vessby, B.
- Abstract
Eight patients with psoriasis or Darier's disease were studied during 1–3 months of ‘Tigason’ treatment (0.7–0.8 mg/kg body weight). The levels of triglycerides and cholesterol in whole serum and in different lipoprotein fractions were repeatedly determined. Before treatment all lipid values were within the normal range. During treatment the values changed gradually and five of the eight patients developed pathological VLDL triglyceride concentrations. A significant increase of VLDL cholesterol and a decrease in the HDL cholesterol was also noted. Until more information is available, prolonged treatment periods with ‘Tigason’ should perhaps be avoided, at least in high risk patients.
- Subjects
ISOPENTENOIDS; STEROLS; CHOLESTEROL; TRIGLYCERIDES; SKIN diseases; HUMAN body composition
- Publication
British Journal of Dermatology, 1981, Vol 105, Issue 2, p201
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1981.tb01206.x