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- Title
Pregnancy outcome in 100 women with autoimmune diseases and anti-Ro/SSA antibodies: a prospective controlled study.
- Authors
Brucato, A; Doria, A; Frassi, M; Castellino, G; Franceschini, F; Faden, D; Pia Pisoni, M; Solerte, L; Muscarà, M; Lojacono, A; Motta, M; Cavazzana, I; Ghirardello, A; Vescovi, F; Tombini, V; Cimaz, R; Gambari, P. F.; Meroni, P. L.; Canesi, B; Tincani, A
- Abstract
Anti-Ro/SSA antibodies are associated with neonatal lupus but are also considered a possible cause for unexplained pregnancy loss and adverse pregnancy outcome. In a large multicentres cohort study we have prospectively followed 100 anti-Ro/SSA positive women (53 systemic lupus erythematosus (SLE)) during their 122 pregnancies and 107 anti-Ro/SSA negative women (58 SLE) (140 pregnancies). Anti-Ro/SSA antibodies were tested by immunoblot and counterimmunoelectrophoresis. Mean gestational age at delivery (38 vs 37.9 weeks), prevalence of pregnancy loss (9.9 vs 18.6%), preterm birth (21.3 vs 13.9%), cesarean sections (49.2 vs 53.4%), premature rupture of membranes (4.9 vs 8.1%), preeclampsia (6.6 vs 8.1%), intrauterinegrowth retardation (0 vs 2.3%) and newborns small for gestational age (11.5 vs 5.8%) were similar in anti-Ro/SSA positive and negative SLE mothers; findings were similar in non-SLE women. Two cases of congenital heart block were observed out of 100 anti-Ro/SSA positive women. In conclusion, anti-Ro/SSA antibodies are responsible for congenital heart block but do not affect other pregnancy outcomes, both in SLE and in non-SLE women. The general outcome of these pregnancies is now very good, if prospectively followed by multidisciplinary teams with ample experience in this field.
- Subjects
PREGNANCY complications; AUTOIMMUNE diseases; SYSTEMIC lupus erythematosus
- Publication
Lupus, 2002, Vol 11, Issue 11, p716
- ISSN
0961-2033
- Publication type
Article
- DOI
10.1191/0961203302lu252oa