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- Title
Use of linezolid in neonatal and pediatric inpatient facilities-results of a retrospective multicenter survey.
- Authors
Simon, A.; Müllenborn, E.; Prelog, M.; Schenk, W.; Holzapfel, J.; Ebinger, F.; Klabunde-Cherwon, A.; Faber, J.; Groll, A.; Masjosthusmann, K.; Dohna-Schwake, C.; Beutel, K.; Dirkwinkel, E.; Lehrnbecher, T.; Ammann, R.; Müller, A.
- Abstract
The purpose of this investigation was to describe the use of linezolid in pediatric inpatient facilities. A retrospective multicenter survey including data from nine participating tertiary care pediatric inpatient facilities in Germany and Austria was undertaken. Data on 126 off-label linezolid treatment courses administered to 108 patients were documented. The survey comprises linezolid treatment in a broad spectrum of clinical indications to children of all age groups; the median age was 6.8 years (interquartile range 0.6-15.5 years; range 0.1-21.2 years; ten patients were older than 18 years of age but were treated in pediatric inpatient units). Of the 126 treatment courses, 27 (21%) were administered to preterm infants, 64 (51%) to pediatric oncology patients, and 5% to patients soon after liver transplantation. In 25%, the infection was related to a medical device. Linezolid iv treatment was started after intensive pre-treatment (up to 11 other antibiotics for a median duration of 14 days) and changed to enteral administration in only 4% of all iv courses. In 39 (53%) of 74 courses administered to children older than 1 week and younger than 12 years of age, the dose was not adjusted to age-related pharmacokinetic parameters. In only 17 courses (13%) was a pediatric infectious disease consultant involved in the clinical decision algorithm. Linezolid seemed to have contributed to a favorable outcome in 70% of all treatment courses in this survey. Although retrospective, this survey generates interesting data on the off-label use of linezolid and highlights several important clinical aspects in which the use of this rescue antibiotic in children might be improved.
- Subjects
GERMANY; AUSTRIA; RETROSPECTIVE studies; INPATIENT care; HOSPITAL care of newborn infants; LIVER transplantation; HEALTH surveys
- Publication
European Journal of Clinical Microbiology & Infectious Diseases, 2012, Vol 31, Issue 7, p1435
- ISSN
0934-9723
- Publication type
Article
- DOI
10.1007/s10096-011-1461-1