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Examining Health Outcomes in Juvenile Idiopathic Arthritis: A Genetic Epidemiology Study.
Published in:
ACR Open Rheumatology, 2022, v. 4, n. 4, p. 363, doi. 10.1002/acr2.11404
By:
- Clarke, Sarah L. N.;
- Richmond, Rebecca C.;
- Zheng, Jie;
- Spiller, Wes;
- Ramanan, Athimalaipet V.;
- Sharp, Gemma C.;
- Relton, Caroline L.
Publication type:
Article
Epigenome-wide association study of asthma and wheeze in childhood and adolescence.
Published in:
Clinical Epigenetics, 2017, v. 9, p. 1, doi. 10.1186/s13148-017-0414-7
By:
- Arathimos, Ryan;
- Suderman, Matthew;
- Sharp, Gemma C.;
- Burrows, Kimberley;
- Granell, Raquel;
- Tilling, Kate;
- Gaunt, Tom R.;
- Henderson, John;
- Ring, Susan;
- Richmond, Rebecca C.;
- Relton, Caroline L.
Publication type:
Article
Distinct DNA methylation profiles in subtypes of orofacial cleft.
Published in:
Clinical Epigenetics, 2017, v. 9, p. 1, doi. 10.1186/s13148-017-0362-2
By:
- Sharp, Gemma C.;
- Ho, Karen;
- Davies, Amy;
- Stergiakouli, Evie;
- Humphries, Kerry;
- McArdle, Wendy;
- Sandy, Jonathan;
- Smith, George Davey;
- Lewis, Sarah J.;
- Relton, Caroline L.
Publication type:
Article
DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies.
Published in:
Genome Medicine, 2020, v. 12, n. 1, p. N.PAG, doi. 10.1186/s13073-020-00810-w
By:
- Vehmeijer, Florianne O. L.;
- Küpers, Leanne K.;
- Sharp, Gemma C.;
- Salas, Lucas A.;
- Lent, Samantha;
- Jima, Dereje D.;
- Tindula, Gwen;
- Reese, Sarah;
- Qi, Cancan;
- Gruzieva, Olena;
- Page, Christian;
- Rezwan, Faisal I.;
- Melton, Philip E.;
- Nohr, Ellen;
- Escaramís, Geòrgia;
- Rzehak, Peter;
- Heiskala, Anni;
- Gong, Tong;
- Tuominen, Samuli T.;
- Gao, Lu
Publication type:
Article
Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology.
Published in:
PLoS Genetics, 2018, v. 14, n. 8, p. 1, doi. 10.1371/journal.pgen.1007501
By:
- Howe, Laurence J.;
- Lee, Myoung Keun;
- Sharp, Gemma C.;
- Davey Smith, George;
- St Pourcain, Beate;
- Shaffer, John R.;
- Ludwig, Kerstin U.;
- Mangold, Elisabeth;
- Marazita, Mary L.;
- Feingold, Eleanor;
- Zhurov, Alexei;
- Stergiakouli, Evie;
- Sandy, Jonathan;
- Richmond, Stephen;
- Weinberg, Seth M.;
- Hemani, Gibran;
- Lewis, Sarah J.
Publication type:
Article
Investigating causality in the association between DNA methylation and type 2 diabetes using bidirectional two-sample Mendelian randomisation.
Published in:
Diabetologia, 2023, v. 66, n. 7, p. 1247, doi. 10.1007/s00125-023-05914-7
By:
- Juvinao-Quintero, Diana L.;
- Sharp, Gemma C.;
- Sanderson, Eleanor C. M.;
- Relton, Caroline L.;
- Elliott, Hannah R.
Publication type:
Article
Epigenetics and gestational diabetes: a review of epigenetic epidemiology studies and their use to explore epigenetic mediation and improve prediction.
Published in:
Diabetologia, 2019, v. 62, n. 12, p. 2171, doi. 10.1007/s00125-019-05011-8
By:
- Elliott, Hannah R.;
- Sharp, Gemma C.;
- Relton, Caroline L.;
- Lawlor, Deborah A.
Publication type:
Article
Paternal impact on the life course development of obesity and type 2 diabetes in the offspring.
Published in:
Diabetologia, 2019, v. 62, n. 10, p. 1802, doi. 10.1007/s00125-019-4919-9
By:
- Sharp, Gemma C.;
- Lawlor, Debbie A.
Publication type:
Article
Prevalence and Factors Associated with Behavioral Problems in 5-Year-Old Children Born with Cleft Lip and/or Palate from the Cleft Collective.
Published in:
Cleft Palate Craniofacial Journal, 2024, v. 61, n. 1, p. 40, doi. 10.1177/10556656221119684
By:
- Berman, Samantha;
- Sharp, Gemma C.;
- Lewis, Sarah J.;
- Blakey, Rachel;
- Davies, Amy;
- Humphries, Kerry;
- Wren, Yvonne;
- Sandy, Jonathan R.;
- Stergiakouli, Evie
Publication type:
Article
Epigenetics and Orofacial Clefts: A Brief Introduction.
Published in:
2018
By:
- Sharp, Gemma C.;
- Stergiakouli, Evie;
- Sandy, Jonathan;
- Relton, Caroline
Publication type:
Editorial
A Computational Model of Lipopolysaccharide-Induced Nuclear Factor Kappa B Activation: A Key Signalling Pathway in Infection-Induced Preterm Labour.
Published in:
PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0070180
By:
- Sharp, Gemma C.;
- Ma, Hongwu;
- Saunders, Philippa T. K.;
- Norman, Jane E.
Publication type:
Article
Epigenome-wide association study of asthma and wheeze characterizes loci within HK1.
Published in:
Allergy, Asthma & Clinical Immunology, 2019, v. 15, n. 1, p. N.PAG, doi. 10.1186/s13223-019-0356-z
By:
- Everson, Todd M.;
- Zhang, Hongmei;
- Lockett, Gabrielle A.;
- Kaushal, Akhilesh;
- Forthofer, Melinda;
- Ewart, Susan L.;
- Burrows, Kimberley;
- Relton, Caroline L.;
- Sharp, Gemma C.;
- Henderson, A. John;
- Patil, Veeresh K.;
- Rezwan, Faisal I.;
- Arshad, S. Hasan;
- Holloway, John W.;
- Karmaus, Wilfried
Publication type:
Article
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09671-3
By:
- Küpers, Leanne K.;
- Monnereau, Claire;
- Sharp, Gemma C.;
- Yousefi, Paul;
- Salas, Lucas A.;
- Ghantous, Akram;
- Page, Christian M.;
- Reese, Sarah E.;
- Wilcox, Allen J.;
- Czamara, Darina;
- Starling, Anne P.;
- Novoloaca, Alexei;
- Lent, Samantha;
- Roy, Ritu;
- Hoyo, Cathrine;
- Breton, Carrie V.;
- Allard, Catherine;
- Just, Allan C.;
- Bakulski, Kelly M.;
- Holloway, John W.
Publication type:
Article
SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts.
Published in:
2018
By:
- Beckmeyer-Borowko, Anna;
- Imboden, Medea;
- Rezwan, Faisal I.;
- Wielscher, Matthias;
- Amaral, Andre F. S.;
- Jeong, Ayoung;
- Schaffner, Emmanuel;
- Auvinen, Juha;
- Sebert, Sylvain;
- Karhunen, Ville;
- Bettschart, Robert;
- Turk, Alexander;
- Pons, Marco;
- Stolz, Daiana;
- Kronenberg, Florian;
- Arathimos, Ryan;
- Sharp, Gemma C.;
- Relton, Caroline;
- Henderson, Alexander J.;
- Jarvelin, Marjo-Riitta
Publication type:
journal article
Establishing the relationships between adiposity and reproductive factors: a multivariable Mendelian randomization analysis.
Published in:
BMC Medicine, 2023, v. 21, n. 1, p. 1, doi. 10.1186/s12916-023-03051-x
By:
- Prince, Claire;
- Howe, Laura D.;
- Sharp, Gemma C.;
- Fraser, Abigail;
- Richmond, Rebecca C.
Publication type:
Article
Associations of sex hormone-binding globulin and testosterone with genome-wide DNA methylation.
Published in:
BMC Genetics, 2018, v. 19, n. 1, p. 1, doi. 10.1186/s12863-018-0703-y
By:
- Arathimos, Ryan;
- Sharp, Gemma C.;
- Granell, Raquel;
- Tilling, Kate;
- Relton, Caroline L.
Publication type:
Article
Vitamin D Levels and Risk of Juvenile Idiopathic Arthritis: A Mendelian Randomization Study.
Published in:
Arthritis Care & Research, 2023, v. 75, n. 3, p. 674, doi. 10.1002/acr.24815
By:
- Clarke, Sarah L. N.;
- Mitchell, Ruth E.;
- Sharp, Gemma C.;
- Ramanan, Athimalaipet V.;
- Relton, Caroline L.
Publication type:
Article
"Environmental risk factors associated with juvenile idiopathic arthritis associated uveitis: a systematic review of the literature".
Published in:
Journal of Ophthalmic Inflammation & Infection, 2021, v. 11, n. 1, p. 1, doi. 10.1186/s12348-021-00247-1
By:
- Clarke, Sarah L. N.;
- Mageean, Katie S.;
- Carlton, Henry;
- Simonini, Gabriele;
- Sharp, Gemma C.;
- Relton, Caroline L.;
- Ramanan, Athimalaipet V.
Publication type:
Article
Intersection of menstrual and menopausal health with mental health: implications for general practice.
Published in:
2024
By:
- Sharp, Gemma C;
- Lavu, Deepthi;
- Cooper, Alison;
- Yarlett, Frances;
- Brauer, Ruth
Publication type:
Editorial
Moving from nature to nurture: a systematic review and meta-analysis of environmental factors associated with juvenile idiopathic arthritis.
Published in:
Rheumatology, 2022, v. 61, n. 2, p. 514, doi. 10.1093/rheumatology/keab627
By:
- Clarke, Sarah L N;
- Mageean, Katie S;
- Maccora, Ilaria;
- Harrison, Sean;
- Simonini, Gabriele;
- Sharp, Gemma C;
- Relton, Caroline L;
- Ramanan, Athimalaipet V
Publication type:
Article
Juvenile idiopathic arthritis polygenic risk scores are associated with cardiovascular phenotypes in early adulthood: a phenome-wide association study.
Published in:
Pediatric Rheumatology, 2022, v. 20, n. 1, p. 1, doi. 10.1186/s12969-022-00760-0
By:
- Clarke, Sarah L. N.;
- Jones, Hannah J.;
- Sharp, Gemma C.;
- Easey, Kayleigh E.;
- Hughes, Alun D.;
- Ramanan, Athimalaipet V.;
- Relton, Caroline L.
Publication type:
Article
Assessing the Role of DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio in Rheumatoid Arthritis.
Published in:
2018
By:
- Ambatipudi, Srikant;
- Sharp, Gemma C.;
- Clarke, Sarah L. N.;
- Plant, Darren;
- Tobias, Jonathan H.;
- Evans, David M.;
- Barton, Anne;
- Relton, Caroline L.
Publication type:
journal article
Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium.
Published in:
Human Molecular Genetics, 2017, v. 26, n. 20, p. 4067, doi. 10.1093/hmg/ddx290
By:
- Sharp, Gemma C.;
- Salas, Lucas A.;
- Monnereau, Claire;
- Allard, Catherine;
- Yousefi, Paul;
- Everson, Todd M.;
- Bohlin, Jon;
- Zongli Xu;
- Rae-Chi Huang;
- Reese, Sarah E.;
- Cheng-Jian Xu;
- Baïz, Nour;
- Hoyo, Cathrine;
- Agha, Golareh;
- Roy, Ritu;
- Holloway, John W.;
- Ghantous, Akram;
- Merid, Simon K.;
- Bakulski, Kelly M.;
- Küpers, Leanne K.
Publication type:
Article
Exploring a causal role of DNA methylation in the relationship between maternal vitamin B12 during pregnancy and child's IQ at age 8, cognitive performance and educational attainment: a two-step Mendelian randomization study.
Published in:
Human Molecular Genetics, 2017, v. 26, n. 15, p. 3001, doi. 10.1093/hmg/ddx164
By:
- Caramaschi, Doretta;
- Sharp, Gemma C.;
- Nohr, Ellen A.;
- Berryman, Katie;
- Lewis, Sarah J.;
- Smith, George Davey;
- Relton, Caroline L.
Publication type:
Article
Prenatal and early life influences on epigenetic age in children: a study of mother--offspring pairs from two cohort studies.
Published in:
Human Molecular Genetics, 2016, v. 25, n. 1, p. 191, doi. 10.1093/hmg/ddv456
By:
- Simpkin, Andrew J.;
- Hemani, Gibran;
- Suderman, Matthew;
- Gaunt, Tom R.;
- Lyttleton, Oliver;
- Mcardle, Wendy L.;
- Ring, Susan M.;
- Sharp, Gemma C.;
- Tilling, Kate;
- Horvath, Steve;
- Kunze, Sonja;
- Peters, Annette;
- Waldenberger, Melanie;
- Ward-Caviness, Cavin;
- Nohr, Ellen A.;
- Sørensen, Thorkild I. A.;
- Relton, Caroline L.;
- Smith, George Davey
Publication type:
Article
Exploring a potential mechanistic role of DNA methylation in the relationship between in utero and post‐natal environmental exposures and risk of childhood acute lymphoblastic leukaemia.
Published in:
International Journal of Cancer, 2019, v. 145, n. 11, p. 2933, doi. 10.1002/ijc.32203
By:
- Timms, Jessica A.;
- Relton, Caroline L.;
- Sharp, Gemma C.;
- Rankin, Judith;
- Strathdee, Gordon;
- McKay, Jill A.
Publication type:
Article
DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts.
Published in:
Clinical Epigenetics, 2021, v. 13, n. 1, p. 1, doi. 10.1186/s13148-021-01027-3
By:
- Juvinao-Quintero, Diana L.;
- Marioni, Riccardo E.;
- Ochoa-Rosales, Carolina;
- Russ, Tom C.;
- Deary, Ian J.;
- van Meurs, Joyce B. J.;
- Voortman, Trudy;
- Hivert, Marie-France;
- Sharp, Gemma C.;
- Relton, Caroline L.;
- Elliott, Hannah R.
Publication type:
Article
Maternal and child genetic liability for smoking and caffeine consumption and child mental health: an intergenerational genetic risk score analysis in the ALSPAC cohort.
Published in:
Addiction, 2021, v. 116, n. 11, p. 3153, doi. 10.1111/add.15521
By:
- Schellhas, Laura;
- Haan, Elis;
- Easey, Kayleigh E.;
- Wootton, Robyn E.;
- Sallis, Hannah M.;
- Sharp, Gemma C.;
- Munafò, Marcus R.;
- Zuccolo, Luisa
Publication type:
Article
Transcription Analysis of the Myometrium of Labouring and Non-Labouring Women.
Published in:
PLoS ONE, 2016, v. 11, n. 5, p. 1, doi. 10.1371/journal.pone.0155413
By:
- Sharp, Gemma C.;
- Hutchinson, James L.;
- Hibbert, Nanette;
- Freeman, Tom C.;
- Saunders, Philippa T. K.;
- Norman, Jane E.
Publication type:
Article
COVID-19 and abnormal uterine bleeding: potential associations and mechanisms.
Published in:
Clinical Science, 2024, v. 138, n. 4, p. 153, doi. 10.1042/CS20220280
By:
- Maybin, Jacqueline A.;
- Watters, Marianne;
- Rowley, Bethan;
- Walker, Catherine A.;
- Sharp, Gemma C.;
- Alvergne, Alexandra
Publication type:
Article
The relationships between women's reproductive factors: a Mendelian randomisation analysis.
Published in:
2022
By:
- Prince, Claire;
- Sharp, Gemma C.;
- Howe, Laura D.;
- Fraser, Abigail;
- Richmond, Rebecca C.
Publication type:
journal article
The COVID-19 pandemic and the menstrual cycle: research gaps and opportunities.
Published in:
2022
By:
- Sharp, Gemma C;
- Fraser, Abigail;
- Sawyer, Gemma;
- Kountourides, Gabriella;
- Easey, Kayleigh E;
- Ford, Gemma;
- Olszewska, Zuzanna;
- Howe, Laura D;
- Lawlor, Deborah A;
- Alvergne, Alexandra;
- Maybin, Jacqueline A
Publication type:
journal article
Paternal body mass index and offspring DNA methylation: findings from the PACE consortium.
Published in:
2021
By:
- Sharp, Gemma C;
- Alfano, Rossella;
- Ghantous, Akram;
- Urquiza, Jose;
- Rifas-Shiman, Sheryl L;
- Page, Christian M;
- Jin, Jianping;
- Fernández-Barrés, Silvia;
- Santorelli, Gillian;
- Tindula, Gwen;
- consortium, and 36 other members of the Pregnancy and Childhood Epigenetics (PACE);
- 36 other members of the Pregnancy and Childhood Epigenetics (PACE) consortium;
- and 36 other members of the Pregnancy and Childhood Epigenetics (PACE) consortium
Publication type:
journal article
Cleft lip/palate and educational attainment: cause, consequence or correlation? A Mendelian randomization study.
Published in:
2020
By:
- Dardani, Christina;
- Howe, Laurence J;
- Mukhopadhyay, Nandita;
- Stergiakouli, Evie;
- Wren, Yvonne;
- Humphries, Kerry;
- Davies, Amy;
- Ho, Karen;
- Weinberg, Seth M;
- Marazita, Mary L;
- Mangold, Elisabeth;
- Ludwig, Kerstin U;
- Relton, Caroline L;
- Smith, George Davey;
- Lewis, Sarah J;
- Sandy, Jonathan;
- Davies, Neil M;
- Sharp, Gemma C;
- Davey Smith, George
Publication type:
journal article
An integrative approach to detect epigenetic mechanisms that putatively mediate the influence of lifestyle exposures on disease susceptibility.
Published in:
2019
By:
- Richardson, Tom G;
- Richmond, Rebecca C;
- North, Teri-Louise;
- Hemani, Gibran;
- Smith, George Davey;
- Sharp, Gemma C;
- Relton, Caroline L;
- Davey Smith, George
Publication type:
journal article
The long-term impact of folic acid in pregnancy on offspring DNA methylation: follow-up of the Aberdeen Folic Acid Supplementation Trial (AFAST).
Published in:
2018
By:
- Richmond, Rebecca C;
- Sharp, Gemma C;
- Herbert, Georgia;
- Atkinson, Charlotte;
- Taylor, Caroline;
- Bhattacharya, Sohinee;
- Campbell, Doris;
- Hall, Marion;
- Kazmi, Nabila;
- Gaunt, Tom;
- McArdle, Wendy;
- Ring, Susan;
- Davey Smith, George;
- Ness, Andy;
- Relton, Caroline L
Publication type:
journal article
Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium.
Published in:
2018
By:
- Felix, Janine F;
- Joubert, Bonnie R;
- Baccarelli, Andrea A;
- Sharp, Gemma C;
- Almqvist, Catarina;
- Annesi-Maesano, Isabella;
- Arshad, Hasan;
- Baïz, Nour;
- Bakermans-Kranenburg, Marian J;
- Bakulski, Kelly M;
- Binder, Elisabeth B;
- Bouchard, Luigi;
- Breton, Carrie V;
- Brunekreef, Bert;
- Brunst, Kelly J;
- Burchard, Esteban G;
- Bustamante, Mariona;
- Chatzi, Leda;
- Cheng Munthe-Kaas, Monica;
- Corpeleijn, Eva
Publication type:
journal article
Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of Parents and Children.
Published in:
2015
By:
- Sharp, Gemma C.;
- Lawlor, Debbie A.;
- Richmond, Rebecca C.;
- Fraser, Abigail;
- Simpkin, Andrew;
- Suderman, Matthew;
- Shihab, Hashem A.;
- Lyttleton, Oliver;
- McArdle, Wendy;
- Ring, Susan M.;
- Gaunt, Tom R.;
- Smith, George Davey;
- Relton, Caroline L.;
- Davey Smith, George
Publication type:
journal article
Maternal Dietary Glycemic Index and Glycemic Load in Pregnancy and Offspring Cord Blood DNA Methylation.
Published in:
2022
By:
- Küpers, Leanne K.;
- Fernández-Barrés, Sílvia;
- Mancano, Giulia;
- Johnson, Laura;
- Ott, Raffael;
- Vioque, Jesus;
- Colombo, Marco;
- Landgraf, Kathrin;
- Tobi, Elmar W.;
- Körner, Antje;
- Gaillard, Romy;
- de Vries, Jeanne H.M.;
- Jaddoe, Vincent W.V.;
- Vrijheid, Martine;
- Sharp, Gemma C.;
- Felix, Janine F.
Publication type:
journal article
The impact of paternal alcohol, tobacco, caffeine use and physical activity on offspring mental health: a systematic review and meta-analysis.
Published in:
Reproductive Health, 2021, v. 18, n. 1, p. 1, doi. 10.1186/s12978-021-01266-w
By:
- Easey, Kayleigh E.;
- Sharp, Gemma C.
Publication type:
Article
Collider bias undermines our understanding of COVID-19 disease risk and severity.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-19478-2
By:
- Griffith, Gareth J.;
- Morris, Tim T.;
- Tudball, Matthew J.;
- Herbert, Annie;
- Mancano, Giulia;
- Pike, Lindsey;
- Sharp, Gemma C.;
- Sterne, Jonathan;
- Palmer, Tom M.;
- Davey Smith, George;
- Tilling, Kate;
- Zuccolo, Luisa;
- Davies, Neil M.;
- Hemani, Gibran
Publication type:
Article
Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age.
Published in:
Genome Medicine, 2020, v. 12, n. 1, p. 1, doi. 10.1186/s13073-020-0716-9
By:
- Merid, Simon Kebede;
- Novoloaca, Alexei;
- Sharp, Gemma C.;
- Küpers, Leanne K.;
- Kho, Alvin T.;
- Roy, Ritu;
- Gao, Lu;
- Annesi-Maesano, Isabella;
- Jain, Pooja;
- Plusquin, Michelle;
- Kogevinas, Manolis;
- Allard, Catherine;
- Vehmeijer, Florianne O.;
- Kazmi, Nabila;
- Salas, Lucas A.;
- Rezwan, Faisal I.;
- Zhang, Hongmei;
- Sebert, Sylvain;
- Czamara, Darina;
- Rifas-Shiman, Sheryl L.
Publication type:
Article
DNA Methylation and BMI: Investigating Identified Methylation Sites at HIF3A in a Causal Framework.
Published in:
2016
By:
- Richmond, Rebecca C.;
- Sharp, Gemma C.;
- Ward, Mary E.;
- Fraser, Abigail;
- Lyttleton, Oliver;
- McArdle, Wendy L.;
- Ring, Susan M.;
- Gaunt, Tom R.;
- Lawlor, Debbie A.;
- Smith, George Davey;
- Relton, Caroline L.;
- Davey Smith, George
Publication type:
journal article

Found: 43