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- Title
Relation between circulating oxidized-LDL and metabolic syndrome in children with obesity: the role of hypertriglyceridemic waist phenotype.
- Authors
Calcaterra, Valeria; De Giuseppe, Rachele; Biino, Ginevra; Mantelli, Melissa; Marchini, Sonia; Bendotti, Giulia; Madè, Alexandra; Avanzini, Maria Antonietta; Montalbano, Chiara; Cossellu, Gianguido; Larizza, Daniela; Cena, Hellas
- Abstract
Background: The association between oxidative stress (OS) and metabolic syndrome (MetS) has been reported in adults. We analyzed the relation between circulating oxidized lowdensity lipoproteins (Ox-LDL) and MetS in pediatric ages in order to define whether plasma Ox-LDL levels are correlated to obesity and whether oxidative damage, using serum Ox-LDL levels as a proxy, are associated with MetS. Methods: We enrolled 178 children (11.8 ± 2.6 years). On the basis of a body mass index (BMI) threshold, the subjects were classified as: normal weight BMI <75th percentile; overweight BMI 75-97th percentile; obese BMI >97th percentile. Patients were classified as having MetS if they met three or more of the following criteria for age and sex: BMI >97th percentile, triglyceride levels >95th percentile, high-density lipoprotein (HDL) cholesterol level <5th percentile, systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) >95th percentile and impaired glucose tolerance. Results: Obese children showed increased MetS prevalence (p = 0.001) and higher Ox-LDL levels compared to normal- and overweight subjects (p < 0.05), with a limited relation between Ox-LDL and MetS (p = 0.06). Waist-to-height ratio (W/HtR) (p = 0.02), triglycerides (TG) (p = 0.001) and LDL-cholesterol (p < 0.001) resulted independent predictors of increased plasma Ox-LDL levels. Conclusions: Oxidative damage was correlated with a hypertriglyceridemic waist phenotype and can be a precocious marker of MetS and cardiometabolic risk in obese children.
- Publication
Journal of Pediatric Endocrinology & Metabolism, 2017, Vol 30, Issue 12, p1257
- ISSN
0334-018X
- Publication type
Article
- DOI
10.1515/jpem-2017-0239