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- Title
Blood microRNA 202-3p associates with the risk of essential hypertension by targeting soluble ST2.
- Authors
Lu Li; Danrong Zhong; Yudan Xie; Xinlei Yang; Zuozhong Yu; Dangui Zhang; Xinghua Jiang; Yanqing Wu; Fangqin Wu
- Abstract
MicroRNA (miR)-202-3p has attracted a great deal of attention in the fields of oncology, gynecology, and metabolic disorders. However, its role in cardiovascular diseases remains to be clarified. We previously found that disruption of miR-202-3p mediated regulation of expression of soluble (s)ST2, a decoy receptor for interleukin (IL)-33, promotes essential hypertension (EH). In the present study, we first measured miR-202-3p expression levels in the blood of 182 EH cases and 159 healthy controls using TaqMan assays. miR-202-3p levels were shown to be significantly higher in EH cases than controls (fold change = 3.58, P<0.001). Logistic regression analysis revealed that higher miR-202-3p expression was associated with an increased occurrence of EH (adjusted odds ratio (OR): 1.57; 95% confidence interval (CI), 1.36-1.82; P<0.001). Addition of miR-202-3p to traditional risk factors showed an additive prediction value for EH. Further functional experiments indicated that miR-202-3p could be induced by angiotensin II (Ang II) and inhibited by Ang II-triggered soluble ST2 (sST2) expression in a negative feedback manner. Moreover, blood miR-202-3p levels were negatively correlated with sST2 expression in vivo. Our study shows that blood miR-202-3p levels were significantly associated with the occurrence of EH. These findings indicate that miR-202-3p exerts a protective role against EH by antagonizing the induction of sST2 by Ang II.
- Subjects
ESSENTIAL hypertension; LOGISTIC regression analysis; INTERLEUKIN receptors; BLOOD; ODDS ratio; ANGIOTENSIN II
- Publication
Bioscience Reports, 2020, Vol 40, Issue 5, p1
- ISSN
0144-8463
- Publication type
Article
- DOI
10.1042/BSR20200378