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- Title
Reduced lean body mass: a potential modifiable contributor to the pathophysiology of heart failure.
- Authors
Diaz-Canestro, Candela; Ng, Hung-Fat; Yiu, Kai-Hang; Montero, David
- Abstract
Skeletal muscle composition and Its relation to exercise intolerance in older patients with heart failure and preserved ejection fraction. In the present article, we will focus on the potential role of lean body mass (LBM), a variable plausibly amenable to change, in heart failure (HF). Reduced LBM, notably in women, entailing a curtailment of skeletal muscle mass exceeding the threshold to become a limiting factor, may restrain the overall muscle contraction-induced vasodilatory capacity to decrease total peripheral resistance (TPRpeak) and cardiac afterload at peak exercise, proportionally limiting peak cardiac output (Qpeak) and O2 consumption (VO2peak).
- Subjects
LEAN body mass; HEART failure; AEROBIC capacity; PATHOLOGICAL physiology; CARDIOVASCULAR system; BODY composition
- Publication
European Heart Journal, 2023, Vol 44, Issue 16, p1386
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/eurheartj/ehad130