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- Title
Maturation of Spontaneous Firing Properties after Hearing Onset in Rat Auditory Nerve Fibers: Spontaneous Rates, Refractoriness, and Interfiber Correlations.
- Authors
Wu, Jingjing Sherry; Young, Eric D.; Glowatzki, Elisabeth
- Abstract
Auditory nerve fibers (ANFs) exhibit a range of spontaneous firing rates (SRs) that are inversely correlated with threshold for sounds. To probe the underlying mechanisms and time course ofSRdifferentiation during cochlear maturation, loose-patch extracellular recordings weremadefromANFdendrites using acutely excised rat cochlear preparations of different ages after hearing onset. Diversification of SRs occurred mostly between the second and the third postnatal week. Statistical properties of ANF spike trains showed developmental changes that approach adult-like features in older preparations. Comparison with intracellularly recorded EPSCs revealed that most properties of ANF spike trains derive from the characteristics of presynaptic transmitter release. Pharmacological tests and waveform analysis showed that endogenous firing produces some fraction of ANF spikes, accounting for their unusual properties; the endogenous firing diminishes gradually during maturation. Paired recordings showed that ANFs contacting the same inner hair cell could have different SRs, with no correlation in their spike timing.
- Subjects
NERVE fibers; ACOUSTIC nerve; HAIR cells; HEARING -- Physiological aspects; LABORATORY rats
- Publication
Journal of Neuroscience, 2016, Vol 36, Issue 41, p10584
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.1187-16.2016