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- Title
A phase 1 study of lucatumumab, a fully human anti- CD40 antagonist monoclonal antibody administered intravenously to patients with relapsed or refractory multiple myeloma.
- Authors
Bensinger, William; Maziarz, Richard T.; Jagannath, Sundar; Spencer, Andrew; Durrant, Simon; Becker, Pamela S.; Ewald, Brett; Bilic, Sanela; Rediske, John; Baeck, Johan; Stadtmauer, Edward A.
- Abstract
In this open-label, multicentre, phase 1 study a fully human anti- CD40 antagonist monoclonal antibody, lucatumumab, was evaluated in patients with relapsed/refractory multiple myeloma ( MM). The primary objective was to determine the maximum tolerated dose ( MTD) based on dose-limiting toxicities ( DLTs). Secondary objectives included safety, pharmacokinetics, pharmacodynamics and antimyeloma activity. Twenty-eight patients, enrolled using a standard '3 + 3' dose escalation, received one or two ( n = 3) cycles of lucatumumab 1·0, 3·0, 4·5 or 6·0 mg/kg once weekly for 4 weeks. Common lucatumumab-related adverse events were reversible, mild-to-moderate infusion reactions. Severe adverse events were anaemia, chills, hypercalcaemia and pyrexia (7% each). DLTs included grade 4 thrombocytopenia, grade 3 increased alanine aminotransferase and grade 4 increased lipase ( n = 1 each). The MTD was 4·5 mg/kg. At doses ≥3·0 mg/kg, sustained receptor occupancy (≥87%), observed throughout weekly infusions up to 5 weeks after the last infusion, correlated with an estimated half-life of 4-19 d. Twelve patients (43%) had stable disease, and one patient (4%) maintained a partial response for ≥8 months. These findings indicate that single-agent lucatumumab was well tolerated up to 4·5 mg/kg with modest clinical activity in relapsed/refractory MM, warranting further study as a combination therapy.
- Subjects
CD40 antigen; DISEASE relapse; MONOCLONAL antibodies; MULTIPLE myeloma; PHARMACOKINETICS; PHARMACODYNAMICS; THROMBOCYTOPENIA; LIPASES; PATIENTS
- Publication
British Journal of Haematology, 2012, Vol 159, Issue 1, p58
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2012.09251.x