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- Title
Imatinib resistant BCR- ABL1 mutations at relapse in children with Ph<sup>+</sup> ALL: a Children's Oncology Group ( COG) study.
- Authors
Chang, Bill H.; Willis, Stephanie G.; Stork, Linda; Hunger, Stephen P.; Carroll, William L.; Camitta, Bruce M.; Winick, Naomi J.; Druker, Brian J.; Schultz, Kirk R.
- Abstract
The article discusses the impact of imatinib resistant BCR-ABL1 on children with Philadelphia chromosome positive acute lymphoblastic leukaemia (Ph+ ALL). It is mentioned that, relapsed adults on imatinib monotherapy have a resistant mutation within the kinase domain of BCR-ABL1. It is also mentioned that, tyrosine kinases are essential for Ph+ ALL transformation.
- Subjects
IMATINIB; LYMPHOBLASTIC leukemia; GENETIC mutation; PROTEIN-tyrosine kinases; JUVENILE diseases
- Publication
British Journal of Haematology, 2012, Vol 157, Issue 4, p507
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2012.09039.x