We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The genotype nucleophosmin mutated and FLT3-ITD negative is characterized by high bax/bcl-2 ratio and favourable outcome in acute myeloid leukaemia.
- Authors
Del Poeta, Giovanni; Ammatuna, Emanuele; Lavorgna, Serena; Capelli, Giovanni; Zaza, Serena; Luciano, Fabrizio; Ottone, Tiziana; Del Principe, Maria Ilaria; Buccisano, Francesco; Maurillo, Luca; Panetta, Paola; de Fabritiis, Paolo; Stasi, Roberto; Venditti, Adriano; Amadori, Sergio; Coco, Francesco Lo
- Abstract
Nucleophosmin gene ( NPM1) mutations characterize acute myeloid leukaemia (AML) with normal karyotype and frequently co-exist with FLT3 internal tandem duplications (ITD). We evaluated bcl-2, bax, NPM1 and FLT3-ITD in 222 AML patients. Bax/bcl-2 ratio >0·35 and NPM1 without FLT3-ITD were significantly associated ( P = 0·0001). NPM1-mutated (mt)/ FLT3-ITD negative patients showed a higher complete remission (CR) rate (90%, P = 0·0002) and a longer overall survival (OS, P = 0·00007). NPM1-mt/ FLT3-ITD negative plus bax/bcl-2 > 0·35 subset showed a very high CR rate (96%), very long OS ( P = 0·00005) and disease-free survival ( P = 0·004). The favourable prognosis of NPM1-mt/ FLT3-ITD negative patients might be explained by a higher bax/bcl-2 ratio.
- Subjects
MYELOID leukemia; BONE marrow diseases; GENETIC polymorphisms; POPULATION genetics; PROGNOSIS
- Publication
British Journal of Haematology, 2010, Vol 149, Issue 3, p383
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2010.08098.x