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- Title
Alemtuzumab is safe and effective as immunosuppressive treatment for aplastic anaemia and single-lineage marrow failure: a pilot study and a survey from the EBMT WPSAA.
- Authors
Risitano, Antonio Maria; Selleri, Carmine; Serio, Bianca; Torelli, Giovanni Fernando; Kulagin, Alexander; Maury, Sébastien; Halter, Jörg; Gupta, Vikas; Bacigalupo, Andrea; Soci, Gerard; Tichelli, Andr; Schrezenmeier, Hubert; Marsh, Judith; Passweg, Jakob; Rotoli, Bruno
- Abstract
An alemtuzumab-based experimental immunosuppressive treatment (IST) regimen was investigated in 35 patients with severe aplastic anaemia (SAA), pure red cell (PRCA) or pure white cell aplasia (PWCA). Alemtuzumab total dose was 73–103 mg s.c., followed by cyclosporine. No serious toxicity due to the regimen was observed. Adverse events were clinically irrelevant; infectious events were rare. The total response rate was 58%, 84% and 100% in SAA, PRCA and PWCA, respectively, with corresponding 6 months cumulative response probabilities of 84%, 84% and 100%. Subcutaneous alemtuzumab is a feasible and sufficiently safe IST regimen for patients suffering from immune-mediated marrow failures.
- Subjects
APLASTIC anemia treatment; IMMUNOSUPPRESSIVE agents; PURE red cell aplasia; BONE marrow diseases; DRUG efficacy
- Publication
British Journal of Haematology, 2010, Vol 148, Issue 5, p791
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2009.08027.x