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- Title
Mutations in exon 12 of JAK2 are mainly found in JAK2 V617F-negative polycythaemia vera patients.
- Authors
Kouroupi, Eirini; Zoi, Katerina; Parquet, Nathalie; Zoi, Christine; Kiladjian, Jean-Jacques; Grigoraki, Vassiliki; Vainchenker, William; Lellouche, Franck; Marzac, Christophe; Schlageter, Marie-Hélène; Dosquet, Christine; Scott, Linda M.; Fenaux, Pierre; Loukopoulos, Dimitris; Chomienne, Christine; Cassinat, Bruno
- Abstract
The article focuses on mutations in exon 12 of JAK2. Accordingly, it has been proven that the presence of JAK2 V617 mutation is more useful to discover in patients with true Polycythaemia Vera from those with Idiopathic Erythrocytosis. In about have of the patients with splanchnic vein thrombosis, mutation is also present which is presumed to be caused by an undiagnosed Myeloproliferative Disorder (MPD).
- Subjects
GENETIC mutation; ERYTHROCYTE disorders; MYELOPROLIFERATIVE neoplasms; POLYCYTHEMIA; THROMBOSIS; PATIENTS
- Publication
British Journal of Haematology, 2008, Vol 142, Issue 4, p676
- ISSN
0007-1048
- Publication type
Letter
- DOI
10.1111/j.1365-2141.2008.07223.x