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- Title
Virus-associated hemophagocytic syndrome due to rubella virus and varicella-zoster virus dual infection in patient with adult idiopathic thrombocytopenic purpura.
- Authors
Takeoka, Y.; Hino, M.; Oiso, N.; Nishi, S.; Koh, K.; Yamane, T.; Ohta, K.; Nakamae, H.; Aoyama, Y.; Hirose, A.; Fujino, H.; Takubo, T.; Inoue, T.; Tatsumi, N.; Koh, K R
- Abstract
A 26-year-old woman with idiopathic thrombocytopenic purpura (ITP) was admitted to our hospital because of fever and rash. Blood tests revealed thrombocytopenia, liver dysfunction, coagulopathy, and hyperferritinemia. Bone marrow examination revealed many atypical lymphocytes and some histiocytes with hemophagocytosis. On admission she was diagnosed with rubella virus-associated hemophagocytic syndrome (VHAS), but on laboratory examination, she was seropositive for varicella-zoster virus (VZV)-IgM as well as rubella virus-IgM. She was therefore diagnosed with dual infection by rubella virus and VZV. Her simultaneous rubella virus and VZV infection may have been related to the VAHS pathogenesis. She was treated with prednisolone and gamma globulin therapy and recovered completely.
- Subjects
JAPAN; BONE marrow examination; RUBELLA; OLDER women; THROMBOCYTOPENIA; BLOOD platelet disorders; BILIARY tract; HERPES zoster complications; GAMMA globulins; PROGNOSIS; THROMBOPENIC purpura; PREDNISOLONE; NON-langerhans-cell histiocytosis; DISEASE complications
- Publication
Annals of Hematology, 2001, Vol 80, Issue 6, p361
- ISSN
0939-5555
- Publication type
journal article
- DOI
10.1007/s002770000282