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- Title
Brown Adipose Tissue, Adiposity, and Metabolic Profile in Preschool Children.
- Authors
Mya Thway Tint; Michael, Navin; Sadananthan, Suresh Anand; Jonathan Yinhao Huang; Chin Meng Khoo; Godfrey, Keith M.; Shek, Lynette Pei-Chi; Lek, Ngee; Kok Hian Tan; Yap, Fabian; Velan, S. Sendhil; Gluckman, Peter D.; Yap-Seng Chong; Karnani, Neerja; Shiao-Yng Chan; Leow, Melvin Khee-Shing; Kuan Jin Lee; Yung-Seng Lee; Houchun Harry Hu; Cuilin Zhang
- Abstract
Context: An inverse relationship between brown adipose tissue (BAT) and obesity has previously been reported in older children and adults but is unknown in young children. Objective: We investigated the influence of BAT in thermoneutral condition on adiposity and metabolic profile in Asian preschool children. Design, Setting, and Participants: A total of 198 children aged 4.5 years from a prospective birth cohort study, Growing Up in Singapore Towards Healthy Outcomes (GUSTO) were successfully studied with water-fat magnetic resonance imaging of the supraclavicular and axillary fat depot (FDSA). Regions within FDSA with fat-signal-fraction between 20% and 80% were considered BAT, and percentage BAT (%BAT; 100*BAT volume/FDSA volume) was calculated. Main Outcome Measures: Abdominal adipose tissue compartment volumes, ectopic fat in the soleus muscle and liver, fatty liver index, metabolic syndrome scores, and markers of insulin sensitivity. Results: A 1% unit increase in %BAT was associated with lower body mass index, difference (95% CI), -0.08 (-0.10, -0.06) kg/m2 and smaller abdominal adipose tissue compartment volumes. Ethnicity and sex modified these associations. In addition, each unit increase in %BAT was associated with lower ectopic fat at 4.5 years in the liver, -0.008% (-0.013%, -0.003%); soleus muscle, -0.003% (-0.006%, -0.001%) of water content and lower fatty liver index at 6 years. Conclusions: Higher %BAT is associated with a more favorable metabolic profile. BAT may thus play a role in the pathophysiology of obesity and related metabolic disorders. The observed ethnic and sex differences imply that the protective effect of BAT may vary among different groups.
- Subjects
BROWN adipose tissue; OBESITY; PRESCHOOL children
- Publication
Journal of Clinical Endocrinology & Metabolism, 2021, Vol 106, Issue 10, p2901
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/clinem/dgab447