We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Changes of Branched-Chain Amino Acids and Ectopic Fat in Response to Weight-loss Diets: the POUNDS Lost Trial.
- Authors
Xiang Li; Dianjianyi Sun; Tao Zhou; Hao Ma; Heianza, Yoriko; Zhaoxia Liang; Bray, George A.; Sacks, Frank M.; Lu Qi; Li, Xiang; Sun, Dianjianyi; Zhou, Tao; Ma, Hao; Liang, Zhaoxia; Qi, Lu
- Abstract
<bold>Context: </bold>Recent evidence has related circulating branch-chained amino acids (BCAAs) to ectopic fat distribution.<bold>Objective: </bold>To investigate the associations of changes in plasma BCAAs induced by weight-loss diet interventions with hepatic fat and abdominal fat, and potential modification by different diets.<bold>Design, Setting, and Participants: </bold>The current study included 184 participants from the 2-year Preventing Overweight and Using Novel Dietary Strategies (POUNDS Lost) trial with repeated measurements on plasma BCAAs, hepatic fat, and abdominal fat over 2 years.<bold>Main Outcome Measures: </bold>Repeated measurements of hepatic fat, abdominal fat distribution, including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and total adipose tissue (TAT).<bold>Results: </bold>Over 2 years, a decrease in total plasma BCAAs was significantly associated with improvement in hepatic density (a marker for hepatic fat; P = 0.02) and reductions in abdominal fat, including VAT, SAT, and TAT (all P < 0.05) in the main analyses. Additionally, we observed that decreases in BCAAs were associated with decreased insulin, homeostasis model assessment of insulin resistance, and triglycerides, independent of weight loss (all P < 0.05). Moreover, we found that dietary protein intake significantly modified the relation between changes in total plasma BCAAs and hepatic density at 6 months (Pinteraction = 0.01). Participants with a larger decrease in total BCAAs showed a greater increase in hepatic density when consuming a high-protein diet, compared with those with a smaller decrease or increase in total BCAAs.<bold>Conclusions: </bold>Our findings indicate that weight-loss diet-induced decrease in plasma BCAAs is associated with reductions of hepatic and abdominal fat. In addition, dietary protein intake may modify these associations.
- Subjects
AMINO acids; INSULIN; FAT; BRANCHED chain amino acids; LIPID metabolism; ESSENTIAL amino acids; CARBOHYDRATE content of food; ADIPOSE tissue physiology; REDUCING diets; OBESITY; RESEARCH; ABDOMINAL adipose tissue; LIVER; RESEARCH methodology; EVALUATION research; MEDICAL cooperation; TREATMENT effectiveness; COMPARATIVE studies; WEIGHT loss; RESEARCH funding
- Publication
Journal of Clinical Endocrinology & Metabolism, 2020, Vol 105, Issue 10, p1
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/clinem/dgaa377