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- Title
Relaxant Action of Plumula Nelumbinis Extract on Mouse Airway Smooth Muscle.
- Authors
Tan, Li; Chen, Weiwei; Wei, Ming-Yu; Shen, Jinhua; Yu, Meng-Fei; Yang, Guangzhong; Guo, Donglin; Qin, Gangjian; Ji, Guangju; Liu, Qing-Hua
- Abstract
The traditional herb Plumula Nelumbinis is widely used in the world because it has many biological activities, such as anti-inflammation, antioxidant, antihypertension, and butyrylcholinesterase inhibition. However, the action of Plumula Nelumbinis on airway smooth muscle (ASM) relaxation has not been investigated. A chloroform extract of Plumula Nelumbinis (CEPN) was prepared, which completely inhibited precontraction induced by high K+ in a concentration-dependent manner in mouse tracheal rings, but it had no effect on resting tension. CEPN also blocked voltage-dependent L-type Ca2+ channel- (VDCC-) mediated currents. In addition, ACh-induced precontraction was also completely blocked by CEPN and partially inhibited by nifedipine or pyrazole 3. Besides, CEPN partially reduced ACh-activated nonselective cation channel (NSCC) currents. Taken together, our data demonstrate that CEPN blocked VDCC and NSCC to inhibit Ca2+ influx, resulting in relaxation of precontracted ASM. This finding indicates that CEPN would be a candidate of new potent bronchodilators.
- Subjects
AIRWAY (Anatomy); ANIMAL experimentation; MICE; MUSCLE contraction; SMOOTH muscle; PLANT extracts
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2015, Vol 2015, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2015/523640