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- Title
Computational genes: a tool for molecular diagnosis and therapy of aberrant mutational phenotype.
- Authors
Martínez-Pérez, Israel M.; Gong Zhang; Ignatova, Zoya; Zimmermann, Karl-Heinz
- Abstract
Background: A finite state machine manipulating information-carrying DNA strands can be used to perform autonomous molecular-scale computations at the cellular level. Results: We propose a new finite state machine able to detect and correct aberrant molecular phenotype given by mutated genetic transcripts. The aberrant mutations trigger a cascade reaction: specific molecular markers as input are released and induce a spontaneous self-assembly of a wild type protein or peptide, while the mutational disease phenotype is silenced. We experimentally demostrated in in vitro translation system that a viable protein can be autonomously assembled. Conclusion: Our work demostrates the basic principles of computational genes and particularly, their potential to detect mutations, and as a response thereafter administer an output that suppresses the aberrant disease phenotype and/or restores the lost physiological function.
- Subjects
CELLS; DNA; NUCLEOTIDE sequence; GENETIC transcription; GENES; GENETIC mutation
- Publication
BMC Bioinformatics, 2007, Vol 8, p365
- ISSN
1471-2105
- Publication type
Article
- DOI
10.1186/1471-2105-8-365