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- Title
Two cases of relapses in primary progressive multiple sclerosis after fingolimod withdrawal.
- Authors
Davion, Jean-Baptiste; Cambron, M.; Duhin, E.; Chouraki, A.; Lacour, A.; Labauge, P.; Carra, C.; Ayrignac, X.; Vermersch, P.
- Abstract
We report two cases of primary progressive multiple sclerosis (PPMS) included in the INFORMS cohort, experiencing a relapse related to a single MRI gadolinium-enhancing lesion 3 months after fingolimod withdrawal. These two patients share similarities with relapsing-remitting multiple sclerosis cases described in the same situation, suggesting that the initiating process of the active demyelinating plaques is also present in PPMS, even without relapses, but may be triggered as fingolimod is withdrawn. Although the results of the INFORMS study suggest that fingolimod may not slow down the progression, some PPMS patients might still benefit from a disease-modifying treatment.
- Subjects
FINGOLIMOD; DRUG withdrawal symptoms; DISEASE relapse; DISEASE progression; MAGNETIC resonance imaging
- Publication
Journal of Neurology, 2016, Vol 263, Issue 7, p1361
- ISSN
0340-5354
- Publication type
Article
- DOI
10.1007/s00415-016-8144-x