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- Title
Incidence and pattern of hemolytic anemia after minor ABO-mismatched living-donor lobar lung transplantation.
- Authors
Ohsumi, Akihiro; Chen, Fengshi; Yurugi, Kimiko; Maekawa, Taira; Shoji, Tsuyoshi; Sato, Masaaki; Aoyama, Akihiro; Bando, Toru; Date, Hiroshi
- Abstract
Purpose: Living-donor lobar lung transplantation (LDLLT) has been successfully performed in Japan. In LDLLT, the recipient usually receives one lower lobe from each of two donors; however, finding two ABO-matched donors is often difficult. Solid organ transplants from donors with minor ABO-mismatches can be complicated by hemolysis. We investigated the incidence of de novo anti-ABO antibody production and hemolysis in patients receiving LDLLT across minor ABO-mismatches. Methods: We evaluated 23 patients who underwent LDLLT between June 2008 and December 2011, including 11 patients who underwent minor ABO-mismatched transplantation. We measured the anti-A/B antibody serum titers, hemoglobin concentrations and indirect bilirubin levels. Results: None of the patients showed any clinical signs of hemolytic anemia (mean follow-up period; 16 months). Two of the 11 patients (18 %) receiving minor ABO-mismatched LDLLTs showed a small amount of de novo anti-B antibodies for a transient period. These patients showed gradual progression of anemia, and weak de novo anti-A/B antibodies were detected with column agglutination technology. The patients received only 2 U of washed type O red blood cells; thereafter, the hemolytic anemia did not develop further in either case. Conclusion: LDLLT across minor ABO-mismatches results in the transient appearance of weak de novo anti-A/B antibodies with a low incidence; thus, this procedure can be a safe treatment.
- Subjects
DISEASE incidence; HEMOLYTIC anemia; ORGAN donors; LUNG transplantation; HEMOLYSIS &; hemolysins; ANTIBODY formation; ANTIBODY titer
- Publication
Surgery Today, 2013, Vol 43, Issue 11, p1250
- ISSN
0941-1291
- Publication type
Article
- DOI
10.1007/s00595-012-0422-3