We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Performance of endobronchial ultrasound transbronchial needle aspiration as the first nodal staging procedure for the determination of programmed death ligand-1 expression in non-small cell lung cancer patients.
- Authors
Polanco, Dinora; Pinilla, Lucía; Gracia-Lavedan, Esther; Gatius, Sonia; Zuil, María; Pardina, Marina; Gómez, Silvia; Barbé, Ferrán
- Abstract
Purpose: The determination of the programmed death ligand-1 (PD-L1) expression is part of the diagnostic algorithm for advanced non-small cell lung cancer (NSCLC) patients. We aimed to analyze the diagnostic performance of EBUS-TBNA performed as first-choice nodal staging procedure for the determination of PD-L1 expression in NSCLC patients. Methods: Longitudinal-prospective study including NSCLC patients diagnosed between January 2018 and October 2019, for whom a primary tumor biopsy sample and an EBUS-TBNA cytological malignant sample were available. Samples with fewer than 100 malignant cells were considered inadequate. PDL-1 IHC 22C3 pharmDx antibody was used. The percentage of tumor cells expressing PD-L1, setting 1% and 50% as cutoff points, was collected. The weighted kappa coefficient was used to assess the concordance of PD-L1 expression. The PD-L1 expression was compared in precision terms. Results: From a total of 43 patients, 53 pairs of samples were obtained, of which 23 (43.4%) were adequate and included for analysis. The weighted kappa coefficient for PD-L1 expression was 0.41 (95% CI 0.15–0.68) and 0.56 (95% CI 0.23–0.9) for cutoff values ≥ 1% and ≥ 50%, respectively. In advanced stages, the weighted kappa coefficient was 0.6 (95% CI 0.3–0.9) and 1 (95% CI 1–1) for PD-L1 expression cutoff values ≥ 1% and ≥ 50%, respectively. EBUS-TBNA showed a sensitivity, specificity, positive predictive value, and negative predictive value of 1 to detect PDL-1 expression ≥ 50% in advanced stages. Conclusion: EBUS-TBNA performed as first nodal staging procedure in advanced NSCLC patients provides reliable specimens for the detection of PD-L1 expression ≥ 50% and could guide immunotherapy.
- Subjects
NON-small-cell lung carcinoma; PROOF &; certification of death; NEEDLE biopsy; CANCER patients; ULTRASONIC imaging
- Publication
Journal of Cancer Research & Clinical Oncology, 2023, Vol 149, Issue 13, p12459
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-023-05039-9