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- Title
Widefield oct-angiography-based classification of sickle cell retinopathy.
- Authors
Bistour, Anna; Mehanna, Carl-Joe; Chuttarsing, Bastian; Colantuono, Donato; Amoroso, Francesca; Beaumont, William; Matri, Khaled El; Souied, Eric H.; Miere, Alexandra
- Abstract
Purpose: To assess the capillary non-perfusion in different concentric sectors on widefield optical coherence tomography angiography (WF-OCTA) and to correlate the ratio of non-perfusion (RNP) to the severity of sickle cell retinopathy (SCR). Methods: This retrospective, cross-sectional study included eyes of patients with various sickle cell disease (SCD) genotypes having undergone WF-OCTA and ultra-widefield color fundus photography (UWF-CFP). Eyes were grouped as no SCR, non-proliferative SCR or proliferative SCR. RNP was assessed on WF-OCTA montage in different field-of-view (FOV) sectors centered on the fovea: 0–10-degrees circle excluding the foveal avascular zone, the 10–30-degrees circle excluding the optic nerve, the 30–60-degrees circle, and the full 60-degrees circle. Results: Forty-two eyes of twenty-eight patients were included. Within each SCR group, mean RNP of the FOV 30–60 sector was higher than all other sectors (p < 0.05). Mean RNP of all sectors were significatively different between no SCR group and proliferative SCR group (p < 0.05). To distinguish no SCR versus non-proliferative SCR FOV 30–60 had a good sensitivity and specificity of 41.67% and 93.33%, respectively (cutoff RNP > 22.72%, AUC = 0.75, 95% CI 0.56–0.94, p = 0.028). To differentiate non-proliferative versus proliferative SCR, FOV 0–10 had good sensitivity and specificity of 33.33% and 91.67%, respectively (cutoff RNP > 18.09, AUC = 0.73, 95% CI 0.53 to 0.93, p = 0.041). To discern no SCR versus proliferative SCR, all sectors had optimal sensitivity and specificity (p < 0.05). Conclusion: WF OCTA-based RNP provides non-invasive diagnostic information regarding the presence and severity of SCR, and correlates with disease stage in certain FOV sectors.
- Subjects
SICKLE cell anemia; OPTICAL coherence tomography; MYOCARDIAL perfusion imaging; CAPILLAROSCOPY; COLOR photography; OPTIC nerve; SENSITIVITY &; specificity (Statistics)
- Publication
Graefe's Archive of Clinical & Experimental Ophthalmology, 2023, Vol 261, Issue 10, p2805
- ISSN
0721-832X
- Publication type
Article
- DOI
10.1007/s00417-023-06115-z