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- Title
Monitoring therapeutic responses of primary bone tumors by diffusion-weighted image: Initial results.
- Authors
Hayashida, Yoshiko; Yakushiji, Toshitake; Awai, Kazuo; Katahira, Kazuhiro; Nakayama, Yoshiharu; Shimomura, Osamu; Kitajima, Mika; Hirai, Toshinori; Yamashita, Yasuyuki; Mizuta, Hiroshi
- Abstract
The purpose of our study was to investigate whether quantitative diffusion-weighted images (DWI) were useful for monitoring the therapeutic response of primary bone tumors. We encountered 18 osteogenic and Ewing sarcomas. Magnetic resonance (MR) images were performed in all patients before and after therapy. We measured the apparent diffusion coefficient (ADC) values, contrast-to-noise ratio (CNR), and tumor volume of the bone tumors pre- and posttreatment. We determined change in ADC value, change in CNR on T2-weighted images (T2WI), change in CNR on gadopentetate dimeglumine (Gd)-T1-weighted images (Gd-T1WI), and change in tumor volume. The bone tumors were divided into two groups: group A was comprised of tumors with less than 90% necrosis after treatment and group B of tumors at least with 90%. Changes in ADC value, tumor volume, and CNR were compared between the groups. Change in the ADC value was statistically greater in group B than that in the group A (p = 0.003). There was no significant difference in the changes in CNR on T2WI (p = 0.683), in CNR on Gd-T1WI (p = 0.763), and tumor volume (p = 0.065). The ADC value on DWI is a promising tool for monitoring the therapeutic response of primary bone sarcomas.
- Subjects
DIFFUSION magnetic resonance imaging; OSTEOSARCOMA; DRUG therapy; BONE tumors; EWING'S sarcoma; TUMOR treatment; ANTINEOPLASTIC agents; MAGNETIC resonance imaging; TREATMENT effectiveness; CONTRAST media; THERAPEUTICS
- Publication
European Radiology, 2006, Vol 16, Issue 12, p2637
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-006-0342-y