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- Title
Selective intra-arterial chemoembolization of pelvic and spine bone metastases.
- Authors
Chiras, Jacques; Adem, Carmen; Vallée, Jean-Noël; Spelle, Laurent; Cormier, Evelyne; Rose, Michèle; Vallée, Jean-Noël; Rose, Michèle
- Abstract
The purpose of this study was to determine the effect of interventional palliative therapy by using chemoembolization on metastatic bone pain and tumor bulk in inoperable metastases where chemotherapy and radiotherapy had failed. Twenty-five patients (mean age: 59 years) underwent chemoembolization of symptomatic lytic lesions involving the spinal column (n=10), iliac bone and sacrum (n=15). The study design consisted of at least three procedures based on combined chemoembolization performed under analog-sedation. Therapeutic agents were carboplatin for selective chemotherapy and pirarubicin mixed with polyvinyl alcohol foam for chemoembolization. Fifteen of 18 (83%) patients had significant pain relief, as shown by the decrease of analgesic drug use. Mean clinical response duration was 12 months. Radiologically, ten patients were stable. A partial response was observed in four patients, while a complete response was seen in two others. Selective intra-arterial chemoembolization gives longer pain relief than embolization, compared to the literature data, probably because of partial response with local anti-cancer drugs.
- Subjects
BONE metastasis; ANALGESIA; PAIN management; MEDICAL radiology; CANCER treatment; ANTINEOPLASTIC agents; ANTINEOPLASTIC antibiotics; BONE tumors; DOXORUBICIN; ILIUM; LONGITUDINAL method; LUMBAR vertebrae; PALLIATIVE treatment; PELVIC bones; SACRUM; THORACIC vertebrae; SPINAL tumors; POLYSTYRENE; PAIN measurement; CARBOPLATIN; INTRA-arterial infusions; CHEMOEMBOLIZATION; TUMOR treatment
- Publication
European Radiology, 2004, Vol 14, Issue 10, p1774
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-004-2240-5