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- Title
Histamine-Induced Bronchial Response after Administration of Placebo, Salbutamol and a Combination of a Beta-2-Adrenergic Drug (Fenoterol) with an Anticholinergic Agent (Ipratropium Bromide) in Asymptomatic Asthma Patients.
- Authors
Fontana, G.; Mugnai, M.; Cresci, F.; Panuccio, P.
- Abstract
We examined 12 non-smoking patients affected by extrinsic bronchial asthma in steady state. Histamine PD20 FEV1 was assessed 4 h after the administration of salbutamol 200 μg, a combination of fenoterol 200 μg and ipratropium bromide 80 μg, and placebo. Despite the absence of any relevant bronchodilator effect, both salbutamol and the combination fenoterol + ipratropium bromide showed a strong protective effect against the bronchial response to histamine compared to placebo, the combination being more effective than salbutamol (p < 0.05). Our data suggest that, when bronchial challenges with histamine are performed, airway response may be a consequence of both a direct action of such an agent on H1 receptors and of an associated cholinergic reflex. Copyright © 1986 S. Karger AG, Basel
- Publication
Respiration, 1986, Vol 50, Issue S2, p201
- ISSN
0025-7931
- Publication type
Article
- DOI
10.1159/000195127