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- Title
IVF outcome in women with endometriosis in relation to tumour necrosis factor and anti-Müllerian hormone.
- Authors
Falconer, H.; Sundqvist, J.; Gemzell-Danielsson, K.; Von Schoultz, B.; D'Hooghe, T. M.; Fried, G.
- Abstract
This study reports on anti-Müllerian hormone (AMH) in serum and follicular fluid (FF) in relation to inflammatory parameters in women with and without endometriosis undergoing IVF. Serum and FF samples were obtained from 72 women, with (n = 34) and without (n = 38) endometriosis, undergoing IVF. The concentrations of AMH, FSH, tumour necrosis factor (TNF), granulocyte-macrophage colony-stimulating factor (GM-CSF), vascular endothelial growth factor (VEGF) and several interleukins were analysed. Women with endometriosis had significantly lower AMH in serum and FF (serum: 6.38 versus 12.8 pM; P < 0.01, FF: 14.0 versus 19.6 pM; P < 0.05). TNF was increased in FF (40.0 versus 30.8 pg/ml, P < 0.05) from women with endometriosis and significantly higher concentrations of IL-15 and GM-CSF were detected in FF (both P < 0.05). During IVF, women with endometriosis responded well to FSH but had lower fertilization rates. Women with endometriosis have elevated concentrations of several cytokines in FF. They respond adequately to exogenous FSH but may have impaired oocyte quality, reflected in lower fertilization rates, presumably resulting from an inflammatory process in the ovaries. Further studies are needed to elucidate the role of AMH in predicting ovarian reserve in women with endometriosis.
- Subjects
HUMAN in vitro fertilization; ENDOMETRIOSIS; TUMOR necrosis factors; GLYCOPROTEIN hormones; FOLLICLE-stimulating hormone; GRANULOCYTE-macrophage colony-stimulating factor; VASCULAR endothelial growth factors; INTERLEUKINS
- Publication
Reproductive BioMedicine Online (Reproductive Healthcare Limited), 2009, Vol 18, Issue 4, p582
- ISSN
1472-6483
- Publication type
Article
- DOI
10.1016/S1472-6483(10)60138-1