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- Title
Current clinical status of F-FLT PET or PET/CT in digestive and abdominal organ oncology.
- Authors
Nakajo, Masatoyo; Kajiya, Yoriko; Jinguji, Megumi; Nakabeppu, Yoshiaki; Nakajo, Masayuki; Nihara, Tohru; Yoshiura, Takashi
- Abstract
Positron emission tomography (PET) or PET/computed tomography (CT) using F-3′-fluoro-3′-deoxythymidine (F-FLT) offers noninvasive assessment of cell proliferation in human cancers in vivo. The present review discusses the current status on clinical applications of F-FLT-PET (or PET/CT) in digestive and abdominal oncology by comparing with F-fluorodeoxyglucose (F-FDG)-PET (or PET/CT). The results of this review show that although F-FLT uptake is lower in most cases of digestive and abdominal malignancies compared with F-FDG uptake, F-FLT-PET can be used to detect primary tumors. F-FLT-PET has shown greater specificity for N staging than F-FDG-PET which can show false-positive uptake in areas of inflammation. However, because of the high background uptake in the liver and bone marrow, it has a limited role of assessing liver and bone metastases. Instead, F-FLT-PET will be a powerful tool for monitoring response to treatment and provide prognostic information in digestive and abdominal oncology.
- Subjects
COMPUTED tomography; POSITRON emission tomography; FLUORODEOXYGLUCOSE F18; BONE marrow; ONCOLOGY
- Publication
Abdominal Radiology, 2017, Vol 42, Issue 3, p951
- ISSN
2366-004X
- Publication type
Article
- DOI
10.1007/s00261-016-0947-9