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- Title
p53 在骨质疏松症中的作用机制及中医药干预研究进展.
- Authors
刘沛; 蒋宜伟; 周玉英; 张夏阳; 麻永胜; 宋重东; 郝东昶; 秦大平
- Abstract
Osteoporosis, as a common degenerative disease in middle-aged and elderly people, has been paid more and more attention. It is caused by the imbalance of bone homeostasis and the disorder of bone metabolism, leading to the decrease in osteoblast differentiation, increase in osteoclast activity, and bone absorption over bone formation. As a tumor suppressor gene, p53 is a key transcription factor. With the in-depth research at home and abroad, p53 not only plays an important role in tumor and cancer, but also plays a key role in the occurrence and development of osteoporosis. A large number of research and analysis have found that p53 is the key target of traditional Chinese medicine in prevention and treatment of osteoporosis. Therefore, the authors review the mechanism of p53 in osteoporosis and the research progress of targeted regulation of p53 in prevention and treatment of osteoporosis with traditional Chinese medicine at home and abroad, so as to provide theoretical basis for the prevention and treatment of osteoporosis and further research.
- Publication
Chinese Journal of Osteoporosis, 2023, Vol 29, Issue 7, p1021
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969/j.issn.1006-7108.2023.07.017