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- Title
Androgens induce oxidative stress and radiation resistance in prostate cancer cells though NADPH oxidase.
- Authors
Lu, J. P.; Monardo, L.; Bryskin, I.; Hou, Z. F.; Trachtenberg, J.; Wilson, B. C.; Pinthus, J. H.
- Abstract
Androgen deprivation therapy (ADT) facilitates the response of prostate cancer (PC) to radiation. Androgens have been shown to induce elevated basal levels of reactive oxygen species (ROS) in PC, leading to adaptation to radiation-induced cytotoxic oxidative stress. Here, we show that androgens increase the expression of p22phox and gp91phox subunits of NADPH oxidase (NOX) and ROS production by NOX2 and NOX4 in PC. Pre-radiation treatment of 22Rv1 human PC cells with NOX inhibitors sensitize the cells to radiation similarly to ADT, suggesting that their future usage may spare the need for adjuvant ADT in PC patients undergoing radiation.
- Subjects
ANDROGENS; TESTOSTERONE; OXIDATIVE stress; PROSTATE cancer; RADIATION
- Publication
Prostate Cancer & Prostatic Diseases, 2010, Vol 13, Issue 1, p39
- ISSN
1365-7852
- Publication type
Article
- DOI
10.1038/pcan.2009.24