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- Title
Long-term prognosis after kidney donation: a propensity score matched comparison of living donors and non-donors from two population cohorts.
- Authors
Janki, Shiromani; Dehghan, Abbas; van de Wetering, Jacqueline; Steyerberg, Ewout W.; Klop, Karel W. J.; Kimenai, Hendrikus J. A. N.; Rizopoulos, Dimitris; Hoorn, Ewout J.; Stracke, Sylvia; Weimar, Willem; Völzke, Henry; Hofman, Albert; Ijzermans, Jan N. M.
- Abstract
Background: Live donor nephrectomy is a safe procedure. However, long-term donor prognosis is debated, necessitating high-quality studies. Methods: A follow-up study of 761 living kidney donors was conducted, who visited the outpatient clinic and were propensity score matched and compared to 1522 non-donors from population-based cohort studies. Primary outcome was kidney function. Secondary outcomes were BMI (kg/m2), incidences of hypertension, diabetes, cardiovascular events, cardiovascular and overall mortality, and quality of life. Results: Median follow-up after donation was 8.0 years. Donors had an increase in serum creatinine of 26 μmol/l (95% CI 24–28), a decrease in eGFR of 27 ml/min/1.73 m2 (95% CI − 29 to − 26), and an eGFR decline of 32% (95% CI 30–33) as compared to non-donors. There was no difference in outcomes between the groups for ESRD, microalbuminuria, BMI, incidence of diabetes or cardiovascular events, and mortality. A lower risk of new-onset hypertension (OR 0.45, 95% CI 0.33–0.62) was found among donors. The EQ-5D health-related scores were higher among donors, whereas the SF-12 physical and mental component scores were lower. Conclusion: Loss of kidney mass after live donation does not translate into negative long-term outcomes in terms of morbidity and mortality compared to non-donors. Trial registration: Dutch Trial Register NTR3795.
- Subjects
PROPENSITY score matching; KIDNEYS; CARDIOVASCULAR diseases; PROGNOSIS
- Publication
European Journal of Epidemiology, 2020, Vol 35, Issue 7, p699
- ISSN
0393-2990
- Publication type
Article
- DOI
10.1007/s10654-020-00647-y