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- Title
D2-40-positive solitary fibrous tumors of the pleura: Diagnostic pitfall of biopsy specimen.
- Authors
Naito, Yoichi; Ishii, Genichiro; Kawai, Osamu; Hasebe, Takahiro; Nishiwaki, Yutaka; Nagai, Kanji; Ochiai, Atsushi
- Abstract
Solitary fibrous tumor of the pleura (SFTP) is an uncommon spindle-cell neoplasm and is sometimes confused with other spindle-cell tumors, such as sarcomatoid mesotheliomas. D2-40 is a new monoclonal antibody recognizing podoplanin and several studies have confirmed the reliability of D2-40 in the diagnosis of pleural mesothelioma. The authors encountered a case of SFTP that was immunoreactive to D2-40. A 56-year-old woman was admitted to hospital because of an abnormal shadow on a chest X-ray. Percutaneous needle biopsy indicated a spindle-cell tumor showing positive immunoreactivity for CD34, supporting the diagnosis of SFTP. However, the tumor was also immunoreactive to D2-40 and thus malignant mesothelioma could not be ruled out. The tumor was surgically resected to make a definitive pathological diagnosis. The tumor had a patternless architecture and immunohistochemistry was positive for CD34 and D2-40 but was negative for calretinin and cytokeratin 5/6. Therefore a pathological diagnosis of SFTP was made. An additional six tumors diagnosed as SFTP were also tested. Focal immunoreactivity to D2-40 was positive in three out of seven cases, including the first case. Care is required in diagnosing biopsy specimens of D2-40-positive pleural spindle-cell tumors, especially in making the differential diagnosis between SFTP and malignant mesothelioma.
- Subjects
PLEURAL tumors; MONOCLONAL antibodies; WOMEN patients; NEEDLE biopsy; IMMUNOHISTOCHEMISTRY; DIAGNOSIS
- Publication
Pathology International, 2007, Vol 57, Issue 9, p618
- ISSN
1320-5463
- Publication type
Article
- DOI
10.1111/j.1440-1827.2007.02148.x