We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Altered thalamic connectivity during spontaneous attacks of migraine without aura: A resting-state fMRI study.
- Authors
Amin, Faisal Mohammad; Hougaard, Anders; Magon, Stefano; Sprenger, Till; Wolfram, Frauke; Rostrup, Egill; Ashina, Messoud
- Abstract
Background Functional connectivity of brain networks may be altered in migraine without aura patients. Functional magnetic resonance imaging (fMRI) studies have demonstrated changed activity in the thalamus, pons and cerebellum in migraineurs. Here, we investigated the thalamic, pontine and cerebellar network connectivity during spontaneous migraine attacks. Methods Seventeen patients with episodic migraine without aura underwent resting-state fMRI scan during and outside of a spontaneous migraine attack. Primary endpoint was a difference in functional connectivity between the attack and the headache-free days. Functional connectivity was assessed in four different networks using seed-based analysis. The chosen seeds were in the thalamus (MNI coordinates x,y,z: right, 22,-24,0 and left, -22,-28,6), pons (right, 8,-24,-32 and left, -8,-24,-32), cerebellum crus I (right, 46,-58,-30 and left, -46,-58,-30) and cerebellum lobule VI (right, 34,-42,-36 and left, -32,-42,-36). Results We found increased functional connectivity between the right thalamus and several contralateral brain regions (superior parietal lobule, insular cortex, primary motor cortex, supplementary motor area and orbitofrontal cortex). There was decreased functional connectivity between the right thalamus and three ipsilateral brain areas (primary somatosensory cortex and premotor cortex). We found no change in functional connectivity in the pontine or the cerebellar networks. Conclusions The study indicates that network connectivity between thalamus and pain modulating as well as pain encoding cortical areas are affected during spontaneous migraine attacks.
- Subjects
MIGRAINE; BRAIN magnetic fields measurement; PATHOLOGICAL physiology; THALAMUS; CEREBELLUM; COMPARATIVE studies; DIAGNOSTIC imaging; MAGNETIC resonance imaging; RESEARCH methodology; MEDICAL cooperation; COMPUTERS in medicine; RESEARCH; EVALUATION research; NEURAL pathways
- Publication
Cephalalgia, 2018, Vol 38, Issue 7, p1237
- ISSN
0333-1024
- Publication type
journal article
- DOI
10.1177/0333102417729113