We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The pathology of bowel cancer screening.
- Authors
Loughrey, Maurice B.; Shepherd, Neil A.
- Abstract
Colorectal cancer screening is widely promulgated in many parts of the world and population screening is occurring in many countries, especially in western Europe. Although, intuitively, it might be thought that the pathology resulting from screening should be straightforward, being mainly that of polyp diagnosis and the biopsy diagnosis and staging of established adenocarcinoma, in fact experience has shown that there are several areas of considerable difficulty and controversy. In the UK somewhat different programmes, all based on faecal occult blood (FOB) screening, have been developed and each has generated similar pathological conundra. These include the biopsy diagnosis of adenocarcinoma, colorectal serrated pathology, the diagnosis and management of polyp cancers and last, but certainly not least, the phenomenon of the large sigmoid colonic adenomatous polyp with epithelial misplacement/pseudo-invasion. Polyp cancers provide especially difficult management conundra and discussion of that management within a multidisciplinary team-based management meeting is regarded as essential in the UK. Large adenomatous polyps of the sigmoid colon with epithelial misplacement are selected into FOB-based screening programmes and have provided extraordinary diagnostic challenges. Finally, the quality assurance procedures introduced for screening can ensure a considerable overall improvement in the quality of lower gastrointestinal tract pathological reporting.
- Subjects
COLON cancer diagnosis; EARLY detection of cancer; PATHOLOGICAL physiology; POLYPS; FECAL occult blood tests; BIOPSY; CANCER treatment
- Publication
Histopathology, 2015, Vol 66, Issue 1, p66
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/his.12530