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- Title
Purinergic Receptors: Key Mediators of HIV-1 Infection and Inflammation.
- Authors
Swartz, Talia H.; Dubyak, George R.; Chen, Benjamin K.; Dittmer, Dirk; Prakash, Hridayesh
- Abstract
Human immunodeficiency virus type 1 (HIV-1) causes a chronic infection that afflicts more than 30 million individuals worldwide. While the infection can be suppressed with potent antiretroviral therapies, individuals infected with HIV-1 have elevated levels of inflammation as indicated by increased T cell activation, soluble biomarkers, and associated morbidity and mortality. A single mechanism linking HIV-1 pathogenesis to this inflammation has yet to be identified. Purinergic receptors are known to mediate inflammation and have been shown to be required for HIV-1 infection at the level of HIV-1 membrane fusion. Here, we review the literature on the role of purinergic receptors in HIV-1 infection and associated inflammation and describe a role for these receptors as potential therapeutic targets.
- Subjects
HIV; INFLAMMATORY mediators; INFLAMMASOMES
- Publication
Frontiers in Immunology, 2015, Vol 6, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2015.00585