We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Extracellular Vesicles in Trypanosomatids: Host Cell Communication.
- Authors
Torrecilhas, Ana Claudia; Soares, Rodrigo Pedro; Schenkman, Sergio; Fernández-Prada, Christopher; Olivier, Martin
- Abstract
Trypanosoma cruzi, Trypanosoma brucei and Leishmania (Trypanosomatidae: Kinetoplastida) are parasitic protozoan causing Chagas disease, African Trypanosomiasis and Leishmaniases worldwide. They are vector borne diseases transmitted by triatomine bugs, Tsetse fly, and sand flies, respectively. Those diseases cause enormous economic losses and morbidity affecting not only rural and poverty areas but are also spreading to urban areas. During the parasite-host interaction, those organisms release extracellular vesicles (EVs) that are crucial for the immunomodulatory events triggered by the parasites. EVs are involved in cell-cell communication and can act as important pro-inflammatory mediators. Therefore, interface between EVs and host immune responses are crucial for the immunopathological events that those diseases exhibit. Additionally, EVs from these organisms have a role in the invertebrate hosts digestive tracts prior to parasite transmission. This review summarizes the available data on how EVs from those medically important trypanosomatids affect their interaction with vertebrate and invertebrate hosts.
- Subjects
EXTRACELLULAR vesicles; CHAGAS' disease; CELL communication; VECTOR-borne diseases; TRYPANOSOMA cruzi; LEISHMANIA; AFRICAN trypanosomiasis; TRYPANOSOMA brucei
- Publication
Frontiers in Cellular & Infection Microbiology, 2020, Vol 10, pN.PAG
- ISSN
2235-2988
- Publication type
Article
- DOI
10.3389/fcimb.2020.602502