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- Title
Laminar specific loss of isocortical presenilin 1 immunoreactivity in Alzheimer's disease. Correlations with the amyloid load and the density of tau-positive neurofibrillary tangles.
- Authors
Colle, M.-A.; Duyckaerts, C.; Laquerriere, A.; Pradier, L.; Czech, C.; Checler, F.; Hauw, J.-J.
- Abstract
Analyzes the relationship between deposits of A beta peptide and tau positive neuronal profiles in presenilin 1 mutation and sporadic Alzheimer's disease. Use of point counting technique and immunohistochemistry; Location of the lesions in the thickness of the cortex; Density of presenelin 1 neuronal profiles.
- Subjects
ALZHEIMER'S disease; GENETIC mutation; PEPTIDES
- Publication
Neuropathology & Applied Neurobiology, 2000, Vol 26, Issue 2, p117
- ISSN
0305-1846
- Publication type
Article
- DOI
10.1046/j.1365-2990.2000.026002117.x