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- Title
A Fast and Powerful Empirical Bayes Method for Genome-Wide Association Studies.
- Authors
Chang, Tianpeng; Wei, Julong; Liang, Mang; An, Bingxing; Wang, Xiaoqiao; Zhu, Bo; Xu, Lingyang; Zhang, Lupei; Gao, Xue; Chen, Yan; Li, Junya; Gao, Huijiang
- Abstract
Simple Summary: Improving statistical power and computational efficiency are always the research foci in genome-wide association studies (GWAS). In this study, we proposed a fast empirical Bayes GWAS method, which is based on the linear mixed model framework. The method is called Fast-EB-LMM in short. Results from simulation studies show that the Fast-EB-LMM has the highest power for quantitative trait nucleotides (QTNs) detection, the highest computational efficiency, and the strongest robustness, as compared with the efficient mixed model association (EMMA) and empirical Bayes (EB). Application to beef cattle population also verified the effectiveness of this method. We believe that Fast-EB-LMM is a valuable additional tool for GWAS. Linear mixed model (LMM) is an efficient method for GWAS. There are numerous forms of LMM-based GWAS methods. However, improving statistical power and computing efficiency have always been the research hotspots of the LMM-based GWAS methods. Here, we proposed a fast empirical Bayes method, which is based on linear mixed models. We call it Fast-EB-LMM in short. The novelty of this method is that it uses a modified kinship matrix accounting for individual relatedness to avoid competition between the locus of interest and its counterpart in the polygene. This property has increased statistical power. We adopted two special algorithms to ease the computational burden: Eigenvalue decomposition and Woodbury matrix identity. Simulation studies showed that Fast-EB-LMM has significantly increased statistical power of marker detection and improved computational efficiency compared with two widely used GWAS methods, EMMA and EB. Real data analyses for two carcass traits in a Chinese Simmental beef cattle population showed that the significant single-nucleotide polymorphisms (SNPs) and candidate genes identified by Fast-EB-LMM are highly consistent with results of previous studies. We therefore believe that the Fast-EB-LMM method is a reliable and efficient method for GWAS.
- Subjects
EMPIRICAL Bayes methods; STATISTICAL power analysis; FASTING; SIMMENTAL cattle; BEEF cattle; BONFERRONI correction; MATRIX decomposition; CATTLE showing
- Publication
Animals (2076-2615), 2019, Vol 9, Issue 6, p305
- ISSN
2076-2615
- Publication type
Article
- DOI
10.3390/ani9060305