We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Quantifying Genetic and Environmental Influence on Gray Matter Microstructure Using Diffusion MRI.
- Authors
Baxi, Madhura; Biase, Maria A Di; Lyall, Amanda E; Cetin-Karayumak, Suheyla; Seitz, Johanna; Ning, Lipeng; Makris, Nikos; Rosene, Douglas; Kubicki, Marek; Rathi, Yogesh
- Abstract
Early neuroimaging work in twin studies focused on studying genetic and environmental influence on gray matter macrostructure. However, it is also important to understand how gray matter microstructure is influenced by genes and environment to facilitate future investigations of their influence in mental disorders. Advanced diffusion MRI (dMRI) measures allow more accurate assessment of gray matter microstructure compared with conventional diffusion tensor measures. To understand genetic and environmental influence on gray matter, we used diffusion and structural MRI data from a large twin and sibling study (N = 840) and computed advanced dMRI measures including return to origin probability (RTOP), which is heavily weighted toward intracellular and intra-axonal restricted spaces, and mean squared displacement (MSD), more heavily weighted to diffusion in extracellular space and large cell bodies in gray matter. We show that while macrostructural features like brain volume are mainly genetically influenced, RTOP and MSD can together tap into both genetic and environmental influence on microstructure.
- Publication
Cerebral Cortex, 2020, Vol 30, Issue 12, p6191
- ISSN
1047-3211
- Publication type
Article
- DOI
10.1093/cercor/bhaa174