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- Title
Glatiramer acetate ameliorates inflammatory bowel disease in mice through the induction of Qa-1-restricted CD8<sup>+</sup> regulatory cells.
- Authors
Yao, Yunliang; Han, Wenzheng; Liang, Jingjing; Ji, Jian; Wang, Jianli; Cantor, Harvey; Lu, Linrong
- Abstract
Inflammatory bowel diseases ( IBDs) are complex multifactorial immunological disorders characterized by dysregulated immune reactivity in the intestine. Here, we investigated the contribution of Qa-1-restricted CD8+ Treg cells in regulating experimental IBD in mice. We found that CD8+ T cells induced by T-cell vaccination ameliorated the pathological manifestations of dextran sulfate sodium induced IBD when adoptively transferred into IBD mice. In addition, CD8+ cell suppressive activity was induced by vaccination with glatiramer acetate ( GA), an FDA-approved drug for multiple sclerosis ( MS). We next showed that GA-induced CD8+ Treg cells worked in a Qa-1-dependent manner and their suppressive activity depends on perforin-mediated cytotoxicity. Finally, we confirmed the role of CD4+ T cells in dextran sulfate sodium induced colitis progression, and clarified that GA-induced CD8+ T cells exerted their therapeutic effects on colitis by targeting pathogenic CD4+ T cells. Our results reveal a new regulatory role of Qa-1-restricted CD8+ Treg cells in IBD and suggest their induction by GA vaccination as a potential therapeutic approach to IBD.
- Publication
European Journal of Immunology, 2013, Vol 43, Issue 1, p125
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.201242758