We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions.
- Authors
Dudas, Gytis; Hong, Samuel L.; Potter, Barney I.; Calvignac-Spencer, Sébastien; Niatou-Singa, Frédéric S.; Tombolomako, Thais B.; Fuh-Neba, Terence; Vickos, Ulrich; Ulrich, Markus; Leendertz, Fabian H.; Khan, Kamran; Huber, Carmen; Watts, Alexander; Olendraitė, Ingrida; Snijder, Joost; Wijnant, Kim N.; Bonvin, Alexandre M.J.J.; Martres, Pascale; Behillil, Sylvie; Ayouba, Ahidjo
- Abstract
Distinct SARS-CoV-2 lineages, discovered through various genomic surveillance initiatives, have emerged during the pandemic following unprecedented reductions in worldwide human mobility. We here describe a SARS-CoV-2 lineage - designated B.1.620 - discovered in Lithuania and carrying many mutations and deletions in the spike protein shared with widespread variants of concern (VOCs), including E484K, S477N and deletions HV69Δ, Y144Δ, and LLA241/243Δ. As well as documenting the suite of mutations this lineage carries, we also describe its potential to be resistant to neutralising antibodies, accompanying travel histories for a subset of European cases, evidence of local B.1.620 transmission in Europe with a focus on Lithuania, and significance of its prevalence in Central Africa owing to recent genome sequencing efforts there. We make a case for its likely Central African origin using advanced phylogeographic inference methodologies incorporating recorded travel histories of infected travellers. Here, the authors describe the emergence and spread of a new potential SARS-CoV-2 variant of interest, B.1.620. They show that this lineage, first identified in Lithuania, has established local transmission in Europe on multiple occasions and likely emerged in Central Africa.
- Subjects
LITHUANIA; SARS-CoV-2; DELETION mutation; EUROPEAN history; NUCLEOTIDE sequencing
- Publication
Nature Communications, 2021, Vol 12, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-021-26055-8