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- Title
Aspirin Positively Contributes to Drosophila Intestinal Homeostasis and Delays Aging through Targeting Imd.
- Authors
Yangyang Zhu; Qingshuang Cai; Xianrui Zheng; Lei Liu; Yongzhi Hua; Beibei Du; Guomin Zhao; Jiangliu Yu; Zhao Zhuo; Zhongwen Xie; Shanming Ji
- Abstract
The intestine, a high-turnover tissue, plays a critical role in regulating aging and health in both vertebrates and invertebrates. Maintaining the epithelial barrier function of the intestine by preserving innate immune homeostasis significantly delays aging and prevents mortality. In an effort to explore effective chemicals and materials that can improve intestinal integrity, we performed a nonbiased screen utilizing Drosophila as an animal model. We showed that long-term uptake of aspirin markedly prevented age-onset gut leakage, the overproliferation of intestinal stem cells, and the dysbiosis of commensal microbiota in fruit flies. Mechanistically, aspirin efficiently downregulated chronic activation of intestinal immune deficiency signaling during aging. Furthermore, our in vivo and in vitro biochemical analyses indicated that aspirin is a negative modulator in control of the K63-linked ubiquitination of Imd. Our findings uncover a novel regulatory mechanism by which aspirin positively modulates intestinal homeostasis, thus delaying aging, in Drosophila.
- Subjects
DROSOPHILA; AGING; NATURAL immunity
- Publication
Aging & Disease, 2021, Vol 12, Issue 7, p1821
- ISSN
2152-5250
- Publication type
Article
- DOI
10.14336/AD.2020.1008