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- Title
Red bean extract reduces inflammation and increases survival in a murine sepsis model.
- Authors
Park, Siwoo; Choi, Ki-Choon; Fang, Minghao; Lim, Yung; Jeon, Young-Mi; Lee, Jeong-Chae
- Abstract
This study used in vitro and in vivo experimental models to investigate the anti-inflammatory potential of the butanol fraction of red bean ethanol extract (BF-RBEE), which contains the biologically active molecule catechin-7-β- d-glucopyranoside. Treatment with BF-RBEE inhibited nitric oxide production in lipopolysaccharide (LPS)-stimulated macrophages through suppression of extracellular signalregulated kinase and IκBα activation. In an in vivo murine sepsis model, oral administration of BF-RBEE improved mouse survival. Specifically, the survival rate of mice injected with LPS was 0 and 40% in ICR and BALB/c mice, respectively, whereas the survival of mice co-treated with BF-RBEE was 100% in both mouse types. This increase in survival with the BF-RBEE administration was correlated with decreased tumor-necrosis factor-α and interferon-γ and increased interleukin-10. Oral administration of BF-RBEE also inhibited total and ovalbumin-specific IgE production in experimental mice. These results suggest the possible usefulness of red beans in the treatment of inflammatory diseases.
- Publication
Food Science & Biotechnology, 2011, Vol 20, Issue 4, p1125
- ISSN
1226-7708
- Publication type
Article
- DOI
10.1007/s10068-011-0153-z