We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effect of low-dose warfarin on D-dimer levels during sickle cell vaso-occlusive crisis: a brief report.
- Authors
Ahmed, Shahid; Siddiqui, Anita K.; Iqbal, Uzma; Sison, Cristina P.; Shahid, Rabia K.; Sheth, Manish; Patel, Dilip V.; Russo, Linda A.
- Abstract
Ahmed S, Siddiqui AK, Iqbal U, Sison CP, Shahid RK, Sheth M, Patel DV, Russo LA. Effect of low-dose warfarin on D-dimer levels during sickle cell vaso-occlusive crisis: a brief report. Eur J Haematol 2004: 72: 213–216. © Blackwell Munksgaard 2004 : To evaluate the activation of clotting systems in patients with sickle cell disease (SCD) by measuring the plasma D-dimer level and to determine the effect of low-dose warfarin on D-dimer level during vaso-occlusive crisis. : Plasma D-dimer level was measured in 65 blood samples of 37 adult patients with SCD who were hospitalized for vaso-occlusive painful crisis. D-dimer level of patients who were on low-dose warfarin was compared with those patients who were not on any anticoagulation treatment. Analysis of variance ( anova) was carried out to determine factors significantly associated with low D-dimer level in patients with SCD. The following factors were included in the anova model; warfarin, homozygous hemoglobin S, history of blood transfusion in past 3 months, hydroxyurea, hemoglobin S%, hemoglobin F%, white blood cell counts, hemoglobin level, platelet count, and plasma fibrinogen level. : Overall median D-dimer level in 65 samples was 2.7 μg fibrinogen equivalent units (FEU)/mL (0.34–4). Patients who were on low-dose warfarin had a median D-dimer level of 0.81 μg FEU/mL (0.34–1.8) compared with 3.1 μg FEU/mL (0.94–4) in those patients who were not on anticoagulation treatment. Using anova to model D-dimer levels, only warfarin was significantly correlated with low D-dimer levels after controlling for other variables. : Patients with SCD during vaso-occulsive painful crisis have an elevated D-dimer level. Low-dose anticoagulation treatment is associated with a significant reduction in the D-dimer levels.
- Subjects
BLOOD coagulation factors; SICKLE cell anemia; DOSE-effect relationship in pharmacology; WARFARIN; FIBRINOGEN; HEMOGLOBINS; ANALYSIS of variance
- Publication
European Journal of Haematology, 2004, Vol 72, Issue 3, p213
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/j.0902-4441.2003.00209.x