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- Title
EVALUATION OF IMMUNOEXPRESSION AND MDR1 PROMOTER METHYLATION LEVELS IN PROSTATIC TISSUE SAMPLES.
- Authors
Moura, Inês; Costa, Vera L.; Pais, Irene; Ribeiro, Franclim R.; Henrique, Rui; Jerónimo, Carmen
- Abstract
Our aims were: (1) To determine the MDR1 methylation levels in tissue of Prostate cancer (PCa), high grade prosta-tic intraepithelial neoplasia (HGPIN), benign prostatic hyperplasia (BPH) and morphologically normal prostate tissue (MNP); (2) to correlate the methylation levels of the MDR1 promoter with the immunoexpression of P-gp. Our results demonstrate that MDR1 hypermethylation constitutes an effective mechanism of P-gp expression regulation. Future studies will be able to evaluaete the impact of these results in the treatment of PCa patients.
- Subjects
METHYLATION; PROSTATE cancer; HYPERPLASIA; TISSUES; ALKYLATION
- Publication
Revista da Faculdade de Ciências da Saúde, 2008, Vol 5, p124
- ISSN
1646-0480
- Publication type
Article