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- Title
Neuroprotection in acute brain injury: an up-to-date review.
- Authors
Stocchetti, Nino; Taccone, Fabio S; Citerio, Giuseppe; Pepe, Paul E; Le Roux, Peter D; Oddo, Mauro; Polderman, Kees H; Stevens, Robert D; Barsan, William; Maas, Andrew Ir; Meyfroidt, Geert; Bell, Michael J; Silbergleit, Robert; Vespa, Paul M; Faden, Alan I; Helbok, Raimund; Tisherman, Samuel; Zanier, Elisa R; Valenzuela, Terence; Wendon, Julia
- Abstract
Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.
- Publication
Critical Care, 2015, Vol 19, Issue 1, p186
- ISSN
1364-8535
- Publication type
journal article
- DOI
10.1186/s13054-015-0887-8