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- Title
Bone cells, sclerostin, and FGF23: what's bred in the bone will come out in the flesh.
- Authors
Ott, Susan M
- Abstract
Bone metabolism is linked to systemic diseases, and new research shows that the bone cells have endocrine functions that affect multiple organs. They secrete sclerostin, FGF23, prostaglandins, and osteocalcin. Pereira et al. examined gene expression of cells grown from bone biopsies of adolescents with renal osteodystrophy, as a first step to understanding how the bone-cell abnormalities contribute to cardiovascular and metabolic problems in these patients.
- Subjects
BONE metabolism; BONE cells; ENDOCRINE glands; SCLEROSTIN; PROSTAGLANDINS; OSTEOCALCIN
- Publication
Kidney International, 2015, Vol 87, Issue 3, p499
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2014.360